Frequency of Metabolic Associated Fatty Liver Disease among Chronic Kidney Disease Patients in Upper Egypt

Document Type : Original research articles

Authors

1 Department of Tropical Medicine and Gastroenterology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

2 Department of Clinical and Chemical Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

3 Department of Internal Medicine, Faculty of Medicine, South Valley University , Qena, Egypt.

Abstract

Background: Chronic kidney disease (CKD) and metabolic-associated fatty liver disease (MAFLD) are increasing chronic illnesses that contribute to a variety of major cardio-metabolic risk factors and pathogenic processes.
Objectives: To estimate the frequency of MAFLD and its risk factors among CKD Patients in Upper Egypt.
Patients and methods: a case-control study entangled 200 individuals with CKD and 60  person without as a  control. All participants underwent a thorough history, physical examination, and laboratory testing which incorporate complete blood count, assessment of neutrophil-lymphocyte ratio (NLR), liver enzymes (ALT, AST), kidney function, estimated glomerular filtration rate (eGFR), and lipid profile. Pelvic-abdominal ultrasound and fibroscan were executed.
Results:  We found a significantly increased proportion of MAFLD, HbA1c and NLR values in the cases group when compared with the control group, where a high prevalence of steatosis and liver stiffness among CKD patients. Multivariate logistic regression analysis demonstrated that high BMI, elevated LDL, elevated liver enzymes (AST & ALT) were predictive risk factors for the existence of MAFLD in the CKD patients.
Conclusion: There is a statistically significant correlation between CKD and MAFLD in the form of increased prevalence of MAFLD in CKD patients.

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SVU-International Journal of Medical Sciences
Volume 5, Issue 2
July 2022
Pages 189-199

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