Role of serum Irisin in Early Detection of Subclinical Atherosclerosis and Endothelial Dysfunction in Patients with Behcet's Disease

Document Type : Reviews Articles.

Authors

1 Rheumatology and Rehabilitation Department, Faculty of Medicine, Sohag University, Sohag, Egypt.

2 Rheumatology and Rehabilitation Department, Faculty of Medicine - Assuit University, Assiut, Egypt.

Abstract

Background: Behçet's disease (BD) is a disease which affects vessels and cause inflammation and affects the function of the endothelium. Irisin is a hormone of metabolism which affects the function of the endothelium and has an effect on the resistance of insulin. The Main histopathological functions of BD are characterized via way of means of acute inflammatory process and persistent systemic vasculitis related to endothelial disorder.
Objectives: to, examine the connection among serum irisin and subclinical atherosclerosis in sufferers with Behçet's ailment. Also, evaluate serum irisin with different nicely modalities used to locate subclinical atherosclerosis and endothelial dysfunctions.
Conclusion: Irisin is an adipocytokine this is associated with energy metabolism and associated with release of insulin and its sensitivity. We determined that serum irisin ranges in sufferers with BD had a poor courting with thickness of the carotid intima, that is a famous indicator for the resistance of insulin . We need further studies in addition to assessment of irisin level and measurement of the carotid intima thickness

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SVU-International Journal of Medical Sciences
Volume 6, Issue 2
July 2023
Pages 399-407

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