Patterns of Circulating Antinuclear Autoantibodies in Malignant Conditions

Ahmed, Rana Khaled Eldowy; Elsaied, Abdelrahman A.; Sayed, Reham Farouk; Ali, Mohamed Mostafa

doi:10.21608/svuijm.2024.255232.1760

Patterns of Circulating Antinuclear Autoantibodies in Malignant Conditions

Document Type : Original research articles

Authors

¹ Department of Clinical and Chemical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt

² Department of Oncology, Faculty of Medicine, South Valley University, Qena, Egypt

10.21608/svuijm.2024.255232.1760

Abstract

Background: Antinuclear antibodies (ANAs) have been reported to be associated with cancers. However, the role of different ANA patterns in cancers is poorly understood.
Objectives: To investigate the expression of ANA patterns in cancer patients.
Patients and methods: This cross-sectional observational study was conducted on 100 patients with newly diagnosed cancer. Patients were selected randomly from the outpatient clinics of Oncology and Nuclear medicine at Qena University Hospitals. All patients were submitted to clinical examination, laboratory testing for CBC, and quantitation of ANA in patient serum. Indirect Immunofluorescence assays were be used for the visual inspection of the nuclear staining patterns.
Results: The mean age of all studied patients was 56.4 ± 16.7 years, there were 35 males (35%) and 65 females (65%). The most common affected organ was the breast (25 patients, 25%) followed by the liver (18 patients, 18%) in all studied patients. ANA was positive in 32 patients (32%) and negative in 68 patients (68%) of the studied patients. ANA was speckled in 24 patients (75%) and homogenous in 8 patients (25%) of patients positive for ANA.
Conclusion: ANA may be used as early detector marker for malignancy.

Keywords

Main Subjects