Clinicopathologic Significance of Fascin Expression in Different Grades of Gliomas

Abdelkareem, Rasha Mokhtar; Abdelnaby, Amira A.; Kenawy, Karam; Alaa Edin, Hala S. E

doi:10.21608/svuijm.2025.363673.2125

Clinicopathologic Significance of Fascin Expression in Different Grades of Gliomas

Document Type : Original research articles

Authors

¹ Pathology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.

² Department of Neurosurgery, Sohag University hospital, Sohag University, Sohag , Egypt.

³ Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

10.21608/svuijm.2025.363673.2125

Abstract

Background: Gliomas account for more than two-thirds of all malignant brain tumors. Fascin is a cytoskeleton cell protein that plays a crucial role in invasion and spread of the tumor. However the exact role is not clear.
Objectives: The purpose of this study is to 1) assess Fascin expression in different types and grades of gliomas and 2) find out the relationship between its expression and the clincopathological factors.
Patients and methods: Immunohistochemical (IHC) staining with Fascin was studied on 70 cases of gliomas using a mouse monoclonal antibody against human fascin protein, immunoreactivity score of cytoplasmic and membranous staining was used to assess the immunoexpression of fascin in tumor cells.
Results: There was a noteworthy correlation discovered between Fascin expression and histological type (p=0.032), and tumor grade (p= 0.02). However, there was no correlation between Fascin expression and age, sex, tumor site, and tumor size.
Conclusion: Fascin is a good marker of predicting poorer outcomes in glioma patients, but further work is needed to implement this marker in clinical practice

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