Background: laparoscopic cholecystectomy became a widespread procedure with less invasive technique for treatment of gallbladder diseases, So control of post-operative pain associated with it became a source for medical researches to find different drugs and modalities other than opioids usually used for these kinds of operations. Objectives: This study aimed to compare ketamine and dexametomidine infusion as an adjuvant to general anesthesia methods for laparoscopic cholecystectomy patients for follow up post-operative pain and vital signs. Patients and methods: This was a prospective clinical-trial conducted at Qena University Hospital in duration from April 2023 to April 2024, involved fifty adult patients divided into Group K (ketamine infusion) and Group D (dexametomidine infusion). General anesthesia was administered to both groups, intraoperative vital signs monitoring was performed, and postoperative pain was measured using the Visual Analogue Scale (VAS). Results: There was significant decrease in group K when compared to group D regarding Follow up VAS score through the first day post-operative (p < 0.05). Intra-Operative HR was significantly increased in group K when compared to group D through time from the start of the operation till end of operation (p < 0.05). When comparing group K to group D, there was a substantial increase in Intra-Operative SBP 10 to 40 minutes after the procedure began (p < 0.05). Conclusion: ketamine provided better pain control although with more elevation in HR and BP than dexametomidine infusion.
Salem, A. G., Abdellatif, A. F., Soliman, M. A., & Ahmed, A. A. (2025). Comparison of Dexmedetomidine versus Ketamine during Laparoscopic Cholecystectomy Regarding Intra-operative Vital signs and Post-operative pain. SVU-International Journal of Medical Sciences, 8(1), 321-335. doi: 10.21608/svuijm.2024.289386.1864
MLA
Abdelraheem Ghanem Salem; Ahmed Fathy Abdellatif; Mohamed Abdelrahman Soliman; Abbady Abdellah Ahmed. "Comparison of Dexmedetomidine versus Ketamine during Laparoscopic Cholecystectomy Regarding Intra-operative Vital signs and Post-operative pain", SVU-International Journal of Medical Sciences, 8, 1, 2025, 321-335. doi: 10.21608/svuijm.2024.289386.1864
HARVARD
Salem, A. G., Abdellatif, A. F., Soliman, M. A., Ahmed, A. A. (2025). 'Comparison of Dexmedetomidine versus Ketamine during Laparoscopic Cholecystectomy Regarding Intra-operative Vital signs and Post-operative pain', SVU-International Journal of Medical Sciences, 8(1), pp. 321-335. doi: 10.21608/svuijm.2024.289386.1864
VANCOUVER
Salem, A. G., Abdellatif, A. F., Soliman, M. A., Ahmed, A. A. Comparison of Dexmedetomidine versus Ketamine during Laparoscopic Cholecystectomy Regarding Intra-operative Vital signs and Post-operative pain. SVU-International Journal of Medical Sciences, 2025; 8(1): 321-335. doi: 10.21608/svuijm.2024.289386.1864
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