Histological and Immunohistochemical changes induced by exposure to different doses of silver nanoparticles in Liver and Lungs of adult Albino rat

Document Type : Original research articles

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Human Anatomy & Embryology Department, Faculty of Medicine, Sohag University, Sohag, Egypt

Abstract

Background: Nowadays there are varied manipulations of the silver nanoparticles (AgNPs) in educative and manufacturing topics; they are employed in surgical implements, orthopedic equipment, tools of family planning and catheters. They are also handled in drug conveyance, antiviral, germicidal and anticancer mediators.
Objectives: Study the changes that occurred due todifferent dosages of silver nanoparticles in the liver and lungs of adult albino rats.
Materials and methods: Silver nanoparticle solution was consumed. A total of 30 adult male albino rats were alienated to three equivalent  groups; group I (control): divided into 2 subgroups, negative and positive with 5 rats each, group II (AgNPs low dose) which was intraperitoneally injected with AgNPs in a dose of 2 mg/kg once daily for 4 weeks, group III ( AgNPs high dose): rats were injected intraperitoneally with AgNPs in a dose of 4 mg/kg body weight once daily for 4 weeks. 24 hours after the last dose, rats were anesthetized and dissected, where the lungs and livers were taken and prepared for hematoxylin and eosin (H&E) and immunohistochemical study.
Results: Histological and immunohistochemical investigations showed the destructive and inflammatory effects of low dose of silver  nanoparticle in the liver and lung tissues of adult rats and in larger doses these toxic effects were more extensive.
Conclusion: The toxicity of silver nanoparticles  caused dose-related deteriorating alterations in the liver and lung tissues.

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SVU-International Journal of Medical Sciences
Volume 8, Issue 1
January -June
January 2025
Pages 170-184

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