TACC3 as a Prognostic Marker in Breast Carcinoma, an Immunohistochemical study in Qena University Hospitals

Document Type : Original research articles

Authors

1 Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

2 Pathology Department, Faculty of Medicine, Assuit University, Assuit, Egypt.

3 General Surgery Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Abstract

Background: Transforming acidic coiled-coil 3 (TACC3) protein is linked to several forms of human cancer. Yet, its precise role in breast cancer (BC) remains unclear.
Objectives: This study aims to evaluate the immunohistochemical (IHC) expression of TACC3 in BC and its correlation with clinicopathological features and hormonal receptors expression.
Patients and methods: TACC3 was immunohistochemically examined in 60 cases of primary BC from the pathology lab at Qena University Hospital (during the period from April 2021 to April 2023). Alongside this analysis, the patients were also assessed for estrogen receptor, progesterone receptor, HER2/neu, and ki67 index.
Results: A statistically significant association between TACC3 with age, lymph node metastasis, tumor necrosis, ER, and PR expression (p values = 0.049, 0.020, 0.006, 0.042 and 0.006, respectively) was detected. There was no statistically significant difference between TACC3 and tumor stage, lymphovascular emboli, perineural invasion, histological type, HER-2 status and Ki67 (p value > 0.05).
Conclusion: These results suggest that TACC3 may be of valuable prognostic value BC. Furthermore, TACC3 might be a potential candidate for targeted therapy.

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SVU-International Journal of Medical Sciences
Volume 8, Issue 1
January -June
January 2025
Pages 104-116

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