Document Type : Original research articles
Authors
1
Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, South Valley University, Qena, Egypt.
2
Public Health and Community Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
3
Anesthesia and Intensive Care Department, Faculty of Medicine, South Valley University, Qena, Egypt
Abstract
Background: Nutritional status affects gastrointestinal cancer prognosis, which treatment worsens. Malnutrition assessment and management by the PG-SGA improves prognosis and treatment tolerance. Malnourished individuals exhibited worse survival, treatment tolerance, and infection risks. Customised diets decrease risks and increase performance.
Objectives: Investigate how tailored nutritional support influences the treatment outcomes of gastrointestinal cancer patients, focusing on the anatomical site-specific responses to various therapeutic interventions.
Patients and methods: A randomized controlled clinical trial at Qena University Hospital included 60 patients with GIT cancer, using PG-SGA for nutritional assessment. Criteria: age 20-65, confirmed GIT cancer. Methods: history, physical exams, tumor biopsies. PG-SGA scores correlated with treatment response and serum protein levels.
Results: Patients were mostly female (60%), the mean age 47.50 years old, and had diabetes (20%) and hypertension (30%). BMI showed 30% underweight, 20% healthy, 20% overweight, and 30% obese. Colon cancer (40%), cholangiocarcinoma (20%), and pancreatic cancer (20%) were predominantly stage IV (60%) and regressive (70%). PG-SGA scores were significantly associated with age, comorbidities, tumor features, treatment response++, and performance status(p<0.001). PG-SGA was positively correlated with performance status (r=0.611, p<0.001), age (r=0.513, p<0.001), and negatively correlated with blood protein levels (r=-0.296, p=0.022). Nutrition assistance is linked to BMI, body surface area, and blood protein levels (p<0.001), highlighting its impact on clinical outcomes.
Conclusion: GI cancer patients need nutritional assessment and support. PG-SGA has identified older men with advanced tumors and comorbidities as high-risk. BMI, body surface area, serum protein and clinical outcomes improve with nutrition support. Regular dietary assessments improve GI cancer prognosis.
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