Document Type : Original research articles
Authors
1
Department of Medical Pharmacology, Faculty of Medicine, Sohag University, Sohag , Egypt
2
Department of Gynecology & Obstetrics, Taibah Faculty of Medicine, Taibah University, Al-Madinah, Saudi Arabia.
3
Department of Pharmaceutics and Pharmaceutical Industries, College of Pharmacy, Taibah University, Medina, Saudi Arabia
4
Department of Clinical and Chemical Pathology, Tanta Faculty of Medicine, Tanta University, Egypt.
5
Department of Internal Medicine, Tanta Faculty of Medicine, Tanta University, Tanta, Egypt
6
Department of Neuropsychiatry, Faculty of Medicine, Sohag University, Sohag , Egypt.
7
Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt. & Department of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman 11196, Jordan.
8
Al-Rayyan National College of Medicine, Al-Madinah, Saudi Arabia. & Department of Medical Parasitology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
9
Department of Restorative Dentistry and Basic Medical Sciences, Faculty of Dentistry, University of Petra, Amman 11196, Jordan. & Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag , Egypt.
10
Department of Basic Medical Sciences, Faculty of Medicine, Sohag University, Sohag, Egypt. & Department of Basic Medical Sciences, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia
11
Department of Basic Medical Sciences, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia
12
Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag , Egypt.
Abstract
Background: The recurring psychological, behavioural, and physical symptoms of premenstrual tension syndrome (PTS) are related to the luteal phase of the menstrual cycle. Its development may be influenced by hormonal influences.
Objectives: To investigate the effects of catecholamines on PTS and possible improvements upon using pharmacological treatments.
Patients and methods: After agreement of participants and ethical committee approval, this randomized controlled trial enrolled 60 obese women with PTS who were split into younger (18-39 years) and older (40-48 years) age groups in comparison to an age-matched healthy control group. All of the study participants' serum levels of adrenaline (epinephrine), and norepinephrine were measured. Utilizing pertinent rating scales, a few psychosomatic PTS symptoms (headache, backache, and stomach bloating) were also assessed.
Results: Compared to the control group, obese women with PTS had significantly higher serum levels of adrenaline, and noradrenaline (p<0.05). Utilizing a combination of therapies, including Metformin, Amiloride/ Hydrochlorthiazide, a calorie-restricted diet, walking exercises, and either Vitazinc®, or Royal vitamin G, significantly (p< 0.01) reduced the hormonal abnormalities. In women with PTS, symptoms of headache, backache, and stomach bloating significantly increased (p< 0.001). Utilizing the combined treatments dramatically improved all of that. In conjunction with the normalization of serum hormone levels, such combined therapies considerably reduced the levels of the aforementioned hormones in the blood and the intensity of all the analysed psychosomatic symptoms (p<0.001).
Conclusion: PTS is related to obesity and is linked to higher serum catecholamines. There were improvements in hormonal abnormalities and psychosomatic symptoms with the given pharmacological treatments.
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