Assessment of Auditory Function in Patients with Acne Vulgaris receiving Oral Isotretinoin

Document Type : Original research articles

Authors

1 Otorhinolaryngology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

2 Dermatology &Andrology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

3 Audiovestibular Unit, Otorhinolaryngology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Abstract

Background: Isotretinoin is the only available drug that affects all stages of acne pathogenesis and the success of the treatment with oral isotretinoin seems to greatly improve the social functioning of acne patients. Side effects of isotretinoin are well known, but ototoxicity is rarely reported, and its mechanism is not clear.
Objectives: This study was designed to address the possible ototoxic effects of oral Isotretinoin on the inner ears of acne patients.
Patients and Methods: Assessment of the selected sample of patients included full history taking as regards hearing loss, tinnitus, vertigo as well as acne vulgaris. General examination, otorhinolaryngological and dermatological examination were performed. Lipid profile, pure-tone audiometry (PTA) as well as auditory brainstem response (ABR) were conducted both prior to and after oral isotretinoin intake.
Results: There was significant difference between serum blood lipids, ABR latencies as well as PTA thresholds at 3000Hz before and after treatment with oral isotretinoin and highly significant difference between PTA thresholds at 4000,6000 and 8000Hz before and after treatment.
Conclusion: Serum blood lipids seemed to be a good predictor of the adverse effects of oral isotretinoin on human inner ears.

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SVU-International Journal of Medical Sciences
Volume 7, Issue 2
July 2024
Pages 202-206

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