Autoimmunity & Type 1 diabetes patients: Review Article

Document Type : Reviews Articles.

Authors

1 Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt

2 Department of Clinical Pathology , Faculty of Medicine, South Valley University, Qena, Egypt.

Abstract

Background: Increased blood glucose levels (hyperglycemia) are a hallmark of type 1 diabetes mellitus (T1DM), a chronic autoimmune illness marked by insulin insufficiency as a result of the destruction of the pancreatic islet cells. T1DMs a widespread metabolic disorder in children. The loss of cells is due to autoimmunity in mostndividuals (70-90%) with T1DM(concomitant with the formation of T1DM-associated autoantibodies). Autoantibodies are often detected months or even years before the start of symptoms in people with T1DM. These autoantibodies are indicators of the onset of autoimmunity rather than pathogens. Many autoimmune diseases have symptoms of T1DM. Such factors may profoundly impact clinical care of the illness, particularly in children. The four most common autoimmune disorders are vitiligo, Addison's disease, celiac disease, and autoimmune thyroid disease.
Objectives:  To outline the association of T1DM as an autoimmune disease with other comorbid autoimmune illnesses
Conclusion: Several endocrine and non-endocrine autoimmune diseases are strongly linked to type 1 diabetes mellitus.

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