Assessment of autoimmune rheumatic diseases activity during pregnancy

Document Type : Original research articles

Authors

1 Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, South Valley University, Qena, Egypt.

2 Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Al-Azhar University (Assiut Branch), Assiut, Egypt.

3 Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Abstract

Background:Autoimmune rheumatic diseases (ARDs) are chronic problems that disproportionately impact females of childbearing age.
Objective: To evaluate the effect of pregnancy on rheumatic disease activity
Patients and Methods: This prospective study was conducted on (70) pregnant patients aged from 18 to 35 years old. They were divided into four groups; (30) with Rheumatoid arthritis, (20) with SLE, (10) with Systemic Sclerosis and (10) with Ankylosing Spondylitis. Routine baseline investigations, auto antibodies and imaging.
Results: There were significant differences between the current study groups as regards the history of hormonal therapy (p<0.001); family history of rheumatic disease (p=0.037). There was statistically significant higher RBCs (p<0.001), Hb (p=0.006), WBCs (p<0.001), platelets count (p<0.001) and HCT (p<0.001) value in RA patients versus other patients groups. The acute phase reactant was significant in AS patients; also both ALT and AST were significantly higher in AS patients (p<0.001).
RA patients had (Anti-CCP + ) and (RF +) in 80% of cases and other 20% were negative , SLE had (ANA+ ) in all cases , Low (C3-C4) in 87.5% , (RF + ) in 12.5% of cases , in SS all cases had (ACA  +) ,(Anti-SCL70 + ) and in AS all cases had (HLA-B27 +) .
Conclusion: The present study pointed to the importance of tight disease control and diagnosis before and during pregnancy as well as the importance of disease activity assessment

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