Evolving phenotype of systemic lupus erythematosus patients and correlation with antibody against c1q: A review article

Document Type : Reviews Articles.

Authors

1 Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Al-Azhar University (Cairo Branch), Cairo, Egypt.

2 Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Al-Azhar University (Assiut Branch), Assiut, Egypt.

3 Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, South Valley University, Qena, Egypt.

4 Clinical Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Abstract

Background: Systemic lupus erythematosus (SLE) is a persistent illness that results in inflammation of connective tissues, including cartilage and the lining of blood vessels, which give structures throughout the body their flexibility and strength. A multi-system autoimmune illness, SLE affects several organ systems. There are several phenotypes of the illness, and clinical symptoms in individuals may range from modest mucocutaneous signs to severe central nervous system involvement affecting multiple organs. SLE is an illness that develops along many immune-pathogenic pathways.
Aim: To explore various phenotypes of SLE and possible role of anti-C1q antibodies in SLE  
Conclusion: Anti-C1q antibodies were strongly associated with lupus disease activity in SLE patients, suggesting that it may be a reliable, sensitive, and non-invasive serological marker for SLE patients with active SLE disease.

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