Diagnostic Accuracy of IL-17A/IL-17F Gene Polymorphism and Anti-Carbamylated Protein Antibody for Rheumatoid Arthritis: Meta-analysis Study (2014-2020)

Ahmed, Samar Sayed; El-Amir, Mostafa I.; El-Feky, Mohamed Ali; Abdelradi, Eman Ragab

doi:10.21608/svuijm.2022.146355.1329

Diagnostic Accuracy of IL-17A/IL-17F Gene Polymorphism and Anti-Carbamylated Protein Antibody for Rheumatoid Arthritis: Meta-analysis Study (2014-2020)

Document Type : Reviews Articles.

Authors

¹ Medical Microbiology and Immunology, Faculty of Medicine, South Valley University , Qena , Egypt

² Department of Medical Microbiology and Immunology, Faculty of Medicine, South Valley University,Qena, Egypt

³ Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University,Assiut, Egypt

⁴ Physical Medicine, Rheumatology & Rehablitition Department ,Faculty of medicine, South Valley University ,Qena ,Egypt.

10.21608/svuijm.2022.146355.1329

Abstract

Background: The anti-CarP antibody is a novel biomarker that might help in the diagnosis of rheumatoid arthritis. Also, the associations between Interleukin-17A and17F gene polymorphism with inflammatory arthritis were inconsistent among previous studies.
Objectives: to evaluate the diagnostic value of the anti-CarP antibody for RA and to determine the relation between IL-17F and IL-17A gene polymorphism with rheumatoid arthritis.
Methods: A literature review of PubMed, PsycINFO, BioMed Central and Medline databases was carried out to identify peer reviewed peer reviewed studies, published between 2014 and 2020.
Results: Fifteen studies were included in total and the pooled sensitivity, specificity, and positive and negative likelihood ratios for anti-CarP antibody were 42% (95% CI, 38% to 45%), 96% (95% CI, 95% to 97%), 10.2 (95% CI, 7.5 to 13.9), and 0.61 (95% CI, 0.57 to 0.65), respectively. The synopsis diagnostic odds ratio was 17 (95% CI, 12 to 24), and the area under summary receiver operator characteristic curve was 80% (95% CI, 77% to 84%). Further, there were significant associations between IL-17rs2275913 G allele with OA, RA susceptibility (P < 0.05) but not AS. A significant association between rs763780 and RA susceptibility was detected in Caucasian populations (P < 0.05).
Conclusion: The moderate value of Anti-CarP antibody in the diagnosis of RA is relatively low sensitivity and high specificity. As well, IL-17F gene rs763780 C allele confers the increasing in possibility of inflammatory arthritis.

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