Background: Apoptosis is an important factor in the development of tumors especially colorectal carcinomas (CRC). Caspase-3 is considered an ideal marker for measuring apoptosis in these tumors. Objectives: To evaluate the Caspase-3 expression and its correlation with the available clinicopathological criteria in patients with CRC. Patients and methods: Fifty cases of CRC removed by colectomy were enrolled in this study. Caspase-3 expression was evaluated by immunohistochemistry (IHC) using streptavidin-biotin-technique. Results: Caspase-3 appeared as brownish nuclear staining and was expressed in all cases of CRCs. Caspase-3 showed positive significant correlation with age (p= 0.046), histological variant (p= 0.02),and negative correlation with tumor grade (p < 0.001), depth of tumor invasion; T stage (p < 0.001) and lymph node status(p < 0.001). Conclusion: High expression of Caspase-3 in CRC patients related to favorable clinicopathological features and could be a potential independent prognostic factor. Caspase-3 may act as a tumor suppressor in CRC.
Ahmed, S. F., Bernaba, C. N., & Muhammad, E. M. (2022). Immunohistochemical Expression of Caspase-3 in Colorectal Carcinoma. SVU-International Journal of Medical Sciences, 5(1), 240-251. doi: 10.21608/svuijm.2022.108052.1246
MLA
Sheren FM Ahmed; Christeen NB Bernaba; Eman M.S. Muhammad. "Immunohistochemical Expression of Caspase-3 in Colorectal Carcinoma". SVU-International Journal of Medical Sciences, 5, 1, 2022, 240-251. doi: 10.21608/svuijm.2022.108052.1246
HARVARD
Ahmed, S. F., Bernaba, C. N., Muhammad, E. M. (2022). 'Immunohistochemical Expression of Caspase-3 in Colorectal Carcinoma', SVU-International Journal of Medical Sciences, 5(1), pp. 240-251. doi: 10.21608/svuijm.2022.108052.1246
VANCOUVER
Ahmed, S. F., Bernaba, C. N., Muhammad, E. M. Immunohistochemical Expression of Caspase-3 in Colorectal Carcinoma. SVU-International Journal of Medical Sciences, 2022; 5(1): 240-251. doi: 10.21608/svuijm.2022.108052.1246
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