Prospective Comparative Study between Silodosin 8 mg Versus Combination of Tadalafil 5mg and Silodosin 4mgfor treatment of Lower Urinary Tract Symptoms related to Benign Prostatic Hyperplasia
Background:In men, lower urinary tract symptoms (LUTS) are associated with benign prostatichyperplasia (BPH). Therapeutic options aim to relax prostate smooth muscle and/or reduce prostate enlargement. Objectives:To evaluate the efficacy of Silodosin 8 mgalone versus the combinationof Tadalafil 5mg and Silodosin 4 mgfor treatment of LUTS related to BPH. Patients and methods: About 203 patients with LUTS of BPH who completed the study up protocolpresented to our department classified into two groups group A (101 patients) received Silodosin 8 mg, group B (102 patients) received the combination of Tadalafil 5mg and Silodosin 4 mg. All results recorded and analyzed with Statistical Package for Social Science® (SPSS) and Microsoft Excel 2010.
Results: The IPSS, QOL, IIEF score, Q-max and PVR showed significantly greater improvement in the combination of Tadalafil 5mg with Silodosin 4mg than monotherapy of Silodosin 8mg.
Conclusions:Despite Silodosin 8mg is well-tolerated and effective treatment option in men with LUTS of BPH, butthe combination of tadalafil 5m and Silodosin 4mg is more effective and feasible for these patients.
AbdelRazek, M., Abolyosr, A., Mohammed, O., Fathy, A., Talaat, M., & Hassan, A. M. (2023). Prospective Comparative Study between Silodosin 8 mg Versus Combination of Tadalafil 5mg and Silodosin 4mgfor treatment of Lower Urinary Tract Symptoms related to Benign Prostatic Hyperplasia. SVU-International Journal of Medical Sciences, 6(1), 578-583. doi: 10.21608/svuijm.2021.66651.1116
MLA
Mostafa AbdelRazek; Ahmad Abolyosr; Omar Mohammed; Atef Fathy; Mohammed Talaat; Ahmed M. Hassan. "Prospective Comparative Study between Silodosin 8 mg Versus Combination of Tadalafil 5mg and Silodosin 4mgfor treatment of Lower Urinary Tract Symptoms related to Benign Prostatic Hyperplasia". SVU-International Journal of Medical Sciences, 6, 1, 2023, 578-583. doi: 10.21608/svuijm.2021.66651.1116
HARVARD
AbdelRazek, M., Abolyosr, A., Mohammed, O., Fathy, A., Talaat, M., Hassan, A. M. (2023). 'Prospective Comparative Study between Silodosin 8 mg Versus Combination of Tadalafil 5mg and Silodosin 4mgfor treatment of Lower Urinary Tract Symptoms related to Benign Prostatic Hyperplasia', SVU-International Journal of Medical Sciences, 6(1), pp. 578-583. doi: 10.21608/svuijm.2021.66651.1116
VANCOUVER
AbdelRazek, M., Abolyosr, A., Mohammed, O., Fathy, A., Talaat, M., Hassan, A. M. Prospective Comparative Study between Silodosin 8 mg Versus Combination of Tadalafil 5mg and Silodosin 4mgfor treatment of Lower Urinary Tract Symptoms related to Benign Prostatic Hyperplasia. SVU-International Journal of Medical Sciences, 2023; 6(1): 578-583. doi: 10.21608/svuijm.2021.66651.1116
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