Left Ventricular Dysfunction in Prediabetic Patients: A review article

Document Type : Reviews Articles.

Authors

1 Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt & Internal Medicine Department ,Arabian Gulf University(AGU),Bahrain

2 Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.

3 Department of Clinical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt.

Abstract

Background: Prediabetes is a common condition that indicates a state between normal glucose metabolism and diabetes. This is considered a dangerous condition because of the high risk of developing diabetes. A recent study in Europe shows that visually impaired fasting increases glucose and impaired glucose tolerance. prevalence of impaired fasting glucose (IFG) levels range from approximately 3%to 5% in the 20 -44 age group and approximately 20% to 30% in the 65-74 age group. Evidence suggesting a link between the risk of neuropathy, nephropathy, early retinopathy, and macrovascular disease and prediabetes. Prediabetes is associated with a 20% increased risk of cardiovascular disease compared to normoglycemic individuals. Several studies have established systolic and diastolic left ventricular dysfunction in prediabetic patients. We aimed to highlight left ventricular dysfunction in Prediabetic patients and to describe the possible underlying mechanisms of this association.
Conclusion : There is a significant association between left ventricular systolic and diastolic dysfunction and prediabetes. The defects underlying prediabetes which include insulin resistance, metabolic syndrome, dyslipidemia, and inflammation, have been implicated to predispose diabetic patients to  increased risk of developing ventricular dysfunction.

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SVU-International Journal of Medical Sciences
Volume 5, Issue 1
January 2022
Pages 261-267

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