Issue Information
Ali A.
Ghweil
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ahmed H.
Abdellah
Department of Obstetrics and Gynecology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mohammed H.
Hassan
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
0
0
https://svuijm.journals.ekb.eg/article_219347_e3d11a20465be8bac02335664c7373fd.pdf
dx.doi.org/10.21608/svuijm.2022.219347
Sleep Apnea Prevalence and Severity among Patients with Type II Diabetes Mellitus
Amr
Abul-hasan
Chest Diseases Department, Faculty of Medicine, Aswan University, Aswan, Egypt
author
Suzan
Salama
Chest Diseases Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
author
Hoda
Makhlouf
Chest Diseases Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
author
Mohammed
Zein El-deen
Internal Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
author
Shazly
Baghdady
Chest Diseases Department, Faculty of Medicine, Aswan University, Aswan, Egypt
author
text
article
2022
eng
Background: The relationship between sleep disorders and diabetes is bidirectional; sleep disorders can raise the risk of developing insulin resistance, while diabetes would worsen sleep quality.
Objectives: Assessment of the prevalence and severity of sleep apnea among patients with type II diabetes mellitus.
Patients and Methods: a prospective cross-sectional study was carried out on 45 cases with type II diabetes mellitus that were either admitted in Aswan University hospital or sought medical advice in the out-patient clinics during the period from 2017 to 2019. For every patient, the demographic and clinical data were collected, blood glucose levels and HBA1c were measured and full night attended polysomnography was done.
Results: 77.78% of the diabetic cases had sleep apnea syndrome. The most common pattern was obstructive sleep apnea (82.86%). Apnea hypopnea index, obstructive sleep apnea and mixed sleep apnea were considerably higher among cases who had clinical picture of neuropathy compared to those without clinical picture of neuropathy. There was a moderate positive correlation between HbA1c with both AHI (P =0.005, r= 0.464) and obstructive sleep apnea (P value 0.016, r= 0.405). Furthermore, there was a mild positive correlation between HbA1c and percentage of time spent with oxygen saturation <90% (TST< 90%) (P =0.022, r =0.385).
Conclusion: The prevalence of sleep apnea and its severity is high among patients with type II diabetes mellitus.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
1
10
https://svuijm.journals.ekb.eg/article_198500_c261cfffbaf924ba16922519b95cecca.pdf
dx.doi.org/10.21608/svuijm.2021.95544.1219
Effects of obesity-related inflammatory markers on psychosomatic manifestations of premenstrual tension syndrome: towards better therapeutic outcomes (An original article)
Reham A.
Mariah
Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt
author
Samia A.
El-Dardiry
Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt
author
Heba A.
Mahmoud
Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt
author
Mohamed M
Mabrouk
Department of Internal Medicine, Faculty of Medicine, Tanta University, Egypt
author
Nawal A.
El-Dardiry
Department of Obstetrics & Gynaecology, Faculty of Medicine, Tanta University, Egypt
author
Hanan Yousef
Aly
Department of Neuropsychiatry, Faculty of Medicine, Sohag University, Egypt
author
Faten M.
Omran
Department of Pharmacology, Faculty of Medicine, Sohag University, Egypt
author
Manal Mohamed Helmy
Nabo
Division of Pediatric Cardiology, Department of Pediatrics, Hail directorate of Health, Hail, Saudi Arabia & Sohag Teaching Hospital, Sohag, Egypt.
author
Tamer M
Soliman
Department of Clinical Pathology, Faculty of Medicine, Sohag University, Egypt
author
Abdelhady Ragab
Abdel-Gawad
Department of Clinical Pathology, Faculty of Medicine, Sohag University, Egypt
author
Nivin
Baiomy
Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt
author
Reda S
Yousef
Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Egypt
author
Nesreen Ali
Mohammed
Department of Public Health and Community Medicine, Faculty of Medicine, Sohag University, Egypt
author
Salah Mohamed
El Sayed
Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Egypt & Department of Clinical Biochemistry, Taibah Faculty of Medicine, Taibah University, Saudi Arabia.
author
MA
Elsemary
Department of Obstetrics & Gynaecology, Faculty of Medicine, Sohag University, Egypt
author
Hytham Mahmoud
Abdel-Latif
Department of Pharmacology, Faculty of Medicine, Sohag University, Egypt
author
text
article
2022
eng
Background: Obesity-induced inflammation facilitates depression and premenstrual tension syndrome. Hypoxia is a common feature of inflammation. Hypoxia inducible factors adapt cells to low oxygen tension and inflammation. Objectives: We aimed to see how obesity, along with Amiloride, Hydrochlorothiazide, Metformin, calorie restriction, and walking exercise, affected psychosomatic characteristics of premenstrual tension syndrome, during a six-month period.Patients and methods: A prior ethical committee approval and informed patients’ consent were taken. This study was performed in Tanta University, Egypt from May 2019 to December 2019. This study aims at evaluating the effects of obesity-induced inflammatory mediators on psychosomatic effects in women having premenstrual tension syndrome. Effects of combined therapy using (Metformin, Amiloride. Hydrochloride/ Hydrochlorthiazide, caloric restriction, half an hour of walking exercise per day, and Vitazinc capsules) treatment was compared to the same combined therapy including Royal vitamin G treatment (instead of Vitazinc) on alleviating psychosomatic manifestations of premenstrual tension syndrome. Sixty obese women having premenstrual tension syndrome were categorized into younger age group (18-39 years) and older age (40-48 years) versus a non-obese age-matched control group. Body mass index in addition to serum tumour necrosis factor-α (TNF- α), hypoxia-inducible factor-1α (HIF-1α) and receptor activator of nuclear factor- kappa-Β ligand (RANKL) were assessed. Related psychosomatic manifestations of premenstrual tension syndrome (edema, anxiety, and fatigue) were also assessed. Results: Obesity significantly increased serum TNF-α (p < 0.01), HIF-1 α (p < 0.01) and RANKL (p < 0.01). Obesity-induced biochemical effects were higher in older obese women than younger ones. Obesity significantly exaggerated the severity of investigated psychosomatic manifestations (p < 0.001). Both combined therapies (including either Vitazinc or Royal vitamin G) significantly and dramatically decreased the percentage of cases having psychosomatic manifestations (p < 0.001) that was closely related to the decreased serum biochemical parameters. Conclusion: Combined therapy containing Royal vitamin G significantly improved serum biochemical parameters and psychosomatic manifestations better than combined therapy containing Vitazinc.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
11
25
https://svuijm.journals.ekb.eg/article_198503_7db58a17af5a74366f9a0a2809ba8211.pdf
dx.doi.org/10.21608/svuijm.2021.91586.1211
Role of functional MRI images in differentiation between Cholesteatoma and recurrent otitis media with granulations
Emad Edeen
Ali
Department of Radio-diagnosis, Faculty of Medicine, South Valley University , Qena , Egypt
author
Wael M.
Wagdy
Department of Radio-diagnosis, Faculty of Medicine, South Valley University , Qena , Egypt
author
Zaki F.
Aref
Department of Otorhinolaryngology, Faculty of Medicine, South Valley University , Qena , Egypt
author
Ahmed
Okasha
Department of Radio-diagnosis, Faculty of Medicine, South Valley University , Qena , Egypt
author
text
article
2022
eng
Background: The use of diffusion-weighted (DW) sequences to distinguish recurrent cholesteatoma from chronic otitis media with granulations has shown to be quite effective. The differential in water molecule diffusion in various biological tissues is used in DW MRI.
Objectives: The goal of this research was to evaluate the analytic exactness of DWI and the change in ADCs of the middle ear cleft cholesteatoma and non-cholesteatomatous tissue, particularly recurrent otitis media single-shot multi echo planar DW images. In the event of cholesteatoma , intraoperative findings and histological data would be used to validate the outcomes. In the event of otitis media, we will either follow up with the patients clinically to see whether their symptoms improve or if they need a CT scan.
Patients and methods: At South Valley University Hospitals, this research was performed on patients with supposed cholesteatoma (supposed clinically or by CT scan) or branded those, as well as patients with suspected recurrence of otitis media who had previously had operation or were preparing for surgery.
Results: Range of Mean ADC values of cases enrolled in this study which calculated by 3D synapse, even cholesteatoma or otitis media varies from 0.4 to 2.35 with mean average 1.028
Conclusion: DWI is a useful technique in the assessment of cholesteatoma because it distinguishes it from otitis media with high specificity, reducing needing next stare procedures in many instances.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
26
33
https://svuijm.journals.ekb.eg/article_198592_72c098e4e4e95a0334a6b57c42bed5ea.pdf
dx.doi.org/10.21608/svuijm.2021.98811.1225
Utility of MRI in diagnosis of molecular subtypes of breast cancer
Ebtsam Ahmed
Mohammed
Department of Radio-Diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt.
author
Mohamed Tharwat Mahmoud
Solyman
Department of Radio-Diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt.
author
Nagham Nabil
Omar
Department of Radio-Diagnosis, Faculty of Medicine, Assiut University, Assiut, Egypt.
author
Nahla Mohamed Ali
Hasan
Department of Radio-Diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt.
author
text
article
2022
eng
Background: Breast cancer is a collection of diseases defined by distinct pathological (e.g., ductal, lobular, mucinous) and molecular characteristics (e.g., ER and PR, HER2 amplification, and more recently transcriptome-based classifications such as luminal and basal cancers). Molecular subtyping is beneficial for the diagnosis and individualized treatment of breast cancer.MRI is a supplemental technique to mammography and ultrasonography for the evaluation of breast lesions and to predict molecular subtypes of breast cancer. Studies have highlighted the value of DCE-MRI in reflecting the anatomic and functional properties of tumors and facilitating treatment.
Objectives: The aim of this work was to assess the utility of MRI as an accurate method for detection of molecular subtypes of breast cancer.
Patients and Methods: a retrospective clinical study of 2-years enrollment duration. The study was conducted at Radiology Department, Assuit University Hospitals on 50 lesions, patient age ranging from 23 to 66 years old with mean age was (46.9 ± SD) years. MR imaging studies were performed using a 1.5 T Magnetom Vision scanner with dedicated bilateral phased-array breast coil (Siemens, Erlangen, Germany). MRI sequences were 1. Axial T1WI. 2. Axial T2WI. 3. Axial STIR. 4. Axial DWI and ADC. 5. DCE-MRI.
Results: The study included 50 lesions; 21 lesions were Luminal A, 15 lesions were Luminal B, 10 lesions were HER2+, and 4 lesions were TN. Histopathology 39 lesions were IDC-NOS, 1 lesion was IDC (medullary type), 7 lesions were mixed pathology IDC + DCIS, and 3 lesions were ILC. As regard the correlation between the histopathological type and grade, both were specific in differentiation between the molecular subtypes. According to the MRI findings it was found that T2 Intratumoral signal intensity, STIR, and the margin of the lesion were highly specific in differentiation, both L.N status and number were found that they were highly specific in differentiation (p <0.001), while size of the lesion, T1WI signal, ADC values were found that they were non-specific in differentiation between the molecular subtypes of breast cancer. Conclusion: Breast MRI may help in assessing different molecular subtypes of breast cancer.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
34
47
https://svuijm.journals.ekb.eg/article_199523_4ae4ee47036e6d1d1da388642a15fbee.pdf
dx.doi.org/10.21608/svuijm.2021.99249.1226
Cognitive impairment in patients with hepatitis C and non-hepatitis C non-alcoholic fatty liver disease: Hospital-based study
Ahmed Fathy
Zaki
Department of Neuropsychiatry, Faculty of Medicine, South Valley University University, Qena, Egypt
author
Ali A.
Ghweil
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, South Valley University University, Qena, Egypt
author
Ahmed Omar
Hamada
Department of Neuropsychiatry, Faculty of Medicine, South Valley University University, Qena, Egypt
author
Ayman
Gamea
Department of Neuropsychiatry, Faculty of Medicine, South Valley University University, Qena, Egypt
author
text
article
2022
eng
Background: Non-alcoholic fatty liver disease (NAFLD) is important cause of hepatic morbidity worldwide. Recently, a significant association between NAFLD and Cognitive dysfunction has been observed. Objectives: To evaluate the association between NAFLD in patientswith or without chronic hepatitis C virus (HCV) infection and cognitive impairment. Patients and methods: The study included 100 NAFLD participants diagnosed by abdominal ultrasound according to guidelines for the diagnosis and management of non -alcoholic fatty liver disease; 50 of them chronically infected with HCV (Group I) and another 50 patients without chronic HCV infection (Group II). Assessment of cognitive functions was done by the Montreal Cognitive Assessment (MoCA), and Trail Making Test (TMT) (part A and B). Socioeconomic Status assessed by socioeconomic status scale. Magnetic resonant imaging of the brain to calculate periventricular white matter hyperintensities. Results: 16% of Group I patients were deficient in Trail-A, Trail-B, and MoCA, while 18% of group II patients were deficient in Trail-A, Trail-B, and MoCA. There is a statistically significant negative correlation between body mass index (BMI) and MoCA(r = - 0.0243, p-value = 0.015) and a significant positive correlation between BMI and Trail A(r = 0.276, p-value = 0.048). Based on the results of multivariate logistic regression analysis, hypertriglyceridemia, and periventricular white matter hyperintensities were predictive for cognitive impairment. Conclusion: NAFLD, Increased BMI and Hypertriglyceridemia showed significant associations with cognitive dysfunction.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
48
57
https://svuijm.journals.ekb.eg/article_199714_d783773be895e5518e75dd3bd82788bb.pdf
dx.doi.org/10.21608/svuijm.2021.100156.1228
Combined effect of negative pressure wound therapy and cryo-air therapy on diabetic wound healing
Mahmoud
Elshazly
Department of Physical therapy for Surgery, Faculty of physical therapy, South Valley University, Qena, Egypt
author
Zeinab M.
Askary
Department of Vascular Surgery, Qena University Hospital, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Diabetic wounds and ulcers are serious complications in diabetic patients that need a long time and high-cost treatment. There are different physical therapy modalities used in wound care; as Laser therapy, magnetic therapy, negative pressure wound therapy and cryo-air therapy. Objectives: this study was conducted to investigate the effect of combining therapy between negative pressure wound therapy (NPWT) and cryo-air therapy on diabetic wound healing.
Patients and Methods: Sixty diabetic patients with large infected diabetic wounds with age between 40-60 years, positive wound culture after surgical debridement selected and randomly divided into three equal groups, group A received routine medical wound care plus NPWT 3 times/ week for 8 weeks, group B received routine medical wound care plus cryotherapy air 3 times/ week for 8 weeks, group C received routine medical wound care plus NPWT followed by cryotherapy air application 3 times/ week for 8 weeks. The patients were assessed by wound surface area and wound culture before treatment, after 4 weeks of treatment, and at the end of treatment (after 8 weeks). Results: there was a significant decrease in wound volume at the post I and post II compared with that at pretreatment in the three groups. Also, there was a significant decrease in wound volume at post-II compared with that at the post I in the three groups. Also, there was a significant decrease in the positive culture at the post I compared with that pretreatment in group B and C and a significant decrease in the positive culture at the post II compared with pretreatment in group A, B and C. There was a significant decrease in positive wound culture of the group C at post I and post II compared with that of the group A and group B. There was a significant decrease in positive wound culture of the group B compared with that of the group A in the post I and at post II. Conclusion: cryo-air therapy and negative pressure wound therapy have a positive effect on wound healing but its combination is more effective.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
58
67
https://svuijm.journals.ekb.eg/article_199753_3ef71ca8eac9c665ce7ea76b875c48f9.pdf
dx.doi.org/10.21608/svuijm.2021.96057.1220
MRI of shoulder instability: Review article
Hamdan Abdelhameed
Aly
Department of Radio-diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Mohammad Hassan
Alkousy
Department of Radio-diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Khaled Fawzy
Zaky
Department of Radio-diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Mohammad Tharwat Mahmoud
Solyman
Department of Radio-diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt
author
text
article
2022
eng
Background: Glenohumeral (GH) instability is a common entity that primarily affects young active populations and athletes in particular. Shoulder dislocation occurs when the humeral head is forced out of the glenoid fossa. Once the soft tissues supporting the shoulder become loose or torn, the shoulder joint becomes prone to dislocations. Various imaging techniques are available for the evaluation of shoulder joint abnormalities including plain radiographs, conventional arthrography, ultrasonography, computed tomography, MRI and MR arthrography. Magnetic resonance imaging is considered the best modality for assessment of shoulder joint pathology as it provides superior multiplaner capability and exceptional soft tissue contrast. MR arthrography, in particular, is more superior to conventional (non-arthrographic) MRI for the detection of the assessment of labral tears and articular cartilage damage. We have searched literatures in PubMed, Google scholar, Egyptian bank of knowledge and science direct.
Conclusion: Various imagingtechniques are useful in assessment of shoulder instability. MRI and MR arthrography are considered the imaging modalities of choice for such cases as they provide superior soft tissue contrast in addition to the benefit gained form joint distension in MR arthrography allowing for better assessment of the labrum.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
68
76
https://svuijm.journals.ekb.eg/article_199754_5eb2d81aaaf03f03d5237a300fe93b36.pdf
dx.doi.org/10.21608/svuijm.2021.99310.1227
Effect of Tramadol administration on the liver of juvenile and adult male albino mice: Comparative histological and histochemical study
Amal Taha
Abou-Elgait
Department of Histology , Faculty of Medicine ,Assuit University, Assiut, Egypt.
author
Gamal Kamel
Mohammed
Department of Histology , Faculty of Veterinary Medicine ,Assuit University, Assiut, Egypt.
author
Eman Ahmed
Abd Elrahim
Department Of Histology , Faculty Of Medicine , South Valley University, Qena, Egypt.
author
Manar Mohammed Abdelrheem
Abdelmageed
Department Of Histology , Faculty Of Medicine , South Valley University, Qena, Egypt.
author
text
article
2022
eng
Background: Tramadol is a broadly used opioid drug;it is an effective analgesic agent for the treatment of moderate to severe pain. The liver is one of the organs responsible for the metabolism and excretion of opioids, which may cause hepatotoxicity. Objectives: The present study was designed to evaluate the effects of tramadol on the liver of both juvenile and adult experimental mice. Materials and methods:Twenty juvenile mice aged 3 weeks and twentyadult mice aged 2 months, were used in the present study.Each group was divided into two subgroups; control and tramadol-treated group (40 mg/kg b.wt., orally for 30 consecutive days). Liver specimens were taken for histopathological examination. Results:This study showed that tramadol treatment induced histopathological changes in both groups (juvenile and adult), but thesechangeswere more prominent and obvious in juvenile than adult group. These changes were manifested by disorganization of liver architecture,cellular degeneration, with congested central and portal veins, associated with inflammatory cells infiltration. Conclusions:Tramadol has harmful effects on the liver of bothjuvenile and adult albino mice and these effects were more obvious in juvenile than in adult mice.Toxic effects of tramadol should keep in mind, even though, the important role it plays as a powerful pain killer.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
77
83
https://svuijm.journals.ekb.eg/article_152417_87a74b55e2bcad5c7b8d1fba808aa448.pdf
dx.doi.org/10.21608/svuijm.2021.61810.1075
Dexmedetomidine ameliorates neuropathic pain in streptozotocin (STZ)-induced diabetic rat model
Somia
Ismail
Department of Pharmacology, Faculty of Medicine, South Valley University, Qena 83523, Egypt
author
Hanan
Farghaly
Department of Pharmacology,
Faculty of Medicine,
Assiut University, Assiut, Egypt
author
Mahmoud
Abdel- Raheem
Department of Pharmacology,
Faculty of Medicine,
Assiut University, Assiut, Egypt
author
Al Shaimaa
Hasan
Department of Pharmacology, Faculty of Medicine, South Valley University, Qena 83523, Egypt
author
text
article
2022
eng
Background: Diabetic neuropathy pain (DNP) is one of the most common complications of diabetes mellitus. It is associated with spontaneous pain, hyperalgesia and allodynia and greatly distresses the patients and compromises their quality of life. Dexmedetomidine (DEX) is a selective and potent α2- adrenoceptor agonist which has ananalgesic effect, reducessympathetic nervous tension and decreases release of glutamate. Thus, dexmedetomidine can be used in the treatment of DNP.
Objectives: We investigated the effect of dexmedetomidine on blood glucose level and neuropathic pain by using streptozotocin (STZ)-induced diabetic rat model.
Materials and Methods: Twenty-four adult male Wistar Albino rats were divided into three groups: vehicle group, streptozotocin group (STZ group) and dexmedetomidine plus streptozotocin group (STZ+DEX group).
Results: It was found that rats injected withSTZ only had a decreased pain threshold compared to the vehicle group and this effect was ameliorated by dexmedetomidine administration.
Conclusion:The current data suggest that dexmedetomidine can ameliorate hyperalgesia in diabetic neuropathy.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
84
91
https://svuijm.journals.ekb.eg/article_121259_589b0a1eb033b10c57a2d5746da37478.pdf
dx.doi.org/10.21608/svuijm.2020.47820.1019
Imaging features of breast cancer molecular subtypes: An Updated Review of the Literature
Ebtsam Ahmed
Mohammed
Department of Radio-Diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt.
author
Mohammad Tharwat Mahmoud
Solyman
Department of Radio-Diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt.
author
Nagham Nabil
Omar
Department of Radio-Diagnosis, Faculty of Medicine, Assiut University, Assiut, Egypt.
author
Nahla Mohamed Ali
Hasan
Department of Radio-Diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt.
author
text
article
2022
eng
Background: Breast carcinoma is classified in keeping with its morphologic features. As regards the WHO classification, the histopathological kinds of the breast carcinoma; ductal carcinomas, lobular carcinomas, and uncommon kinds, these are associated with particular imaging features, primarily based on every kind. Additionally, predictive biologic markers along with estrogen, progesterone receptors, HER2 receptor status, and Ki-67 may be suitable to sub-classify breast carcinoma into the intrinsic subtypes primarily based totally on gene expression profiling into: Luminal A, Luminal B, HER2+, and Triple Negative. Correlation among the imaging and the molecular subtypes has discovered an enormously circumscribed lesions with posterior acoustic enhancement without calcification inside the triple negative breast cancer subtype, microcalcifications are seen with the HER2+ subtype, but speculated lesions of irregular margin and posterior acoustic shadow with the luminal A and B subtypes, MRI is a longtime supplemental method to mammography and ultrasonography for the assessment of breast lesions. Diffusion-weighted MR imaging (DWI) has lately been incorporated into the breast MRI, moreover dynamic contrast enhanced MRI (DCE-MRI).
Conclusion: Understanding medical collaboration of molecular subtypes and imaging features can assist the radiologist to help the clinician to adjust treatment consistent with the patient condition and tumor characteristics.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
92
103
https://svuijm.journals.ekb.eg/article_206535_be105278af4b358c36fb2d1109938d7c.pdf
dx.doi.org/10.21608/svuijm.2021.104214.1238
Clinical Characteristics and Risk Factors of Different Types of Bile Duct Cancer in Upper Egypt
Ahlam M.
Sapra
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mohammed
Wahman
Department of Medical Oncology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mohammed
Tag-Adeen
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Ola Mohammed
Fouad
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt
author
mohamed
Alsenbsy
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.; Department of Internal Medicine, Faculty of Medicine and Medical Sciences (FMMS), Arabian Gulf University (AGU), Bahrain.
author
text
article
2022
eng
Background: Cholangiocarcinoma (CCA) is a cancer that emerges from the biliary epithelium neoplastic transformation and has a steadily increasing incidence and prevalence. It is the 2ndmost prevalent primary hepatic cancer, accounting for around 15% of cases and 3% of GITcancers. Objectives: are to determine risk factors and prevalence for various forms of Cholangiocarcinoma (CCA). Patients and methods: A prospective study was conducted at Qena university hospital on 62 patients with cholangiocarcinoma proved by imaging, cytological or pathological evidence. Complete full history was taken, then full clinical examination and laboratory study were done. Result: Prevalence of distal cholangiocarcinoma was 56.5%, but hilar cholangiocarcinoma was 43.5% (n=27). A significant relation between gender and type of cholangiocarcinoma, where hilar type was more common among females P value= 0.02. Also, a significant relation between smoking and obesity and type of cholangiocarcinoma where distal type was more common among smokers and obese patients (P = 0.05 and P=0.03 respectively). Conclusion:Gender variation, smoking and obesity are the most important risk factors of cholangiocarcinoma, with hilar type more common among females, distal type more common among smokers and obese patients. Distal cholangiocarcinoma is more prevalent than hilar cholangiocarcinoma (56.5% and 43.5% respectively).
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
104
113
https://svuijm.journals.ekb.eg/article_163244_0ade305cb331604094c42375f3e25778.pdf
dx.doi.org/10.21608/svuijm.2021.71173.1161
Rectal indomethacin versus intraperitoneal lidocaine for analgesia after laparoscopic cholecystectomy
Gad
Gad
Department of Anesthesia, ICU, and Pain Management, Faculty of Medicine, South Valley University.Qena,Egypt
author
Hatem Saber
Ali
Department of Anaesthesia, ICU, and Pain Management, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Visceral and shoulder painare among the most frequent reported pain after laparoscopic cholecystectomy (LC).
Objectives: To investigate the effectiveness and clinical value of rectal indomecthacin and intraperitoneal lidocaine for treating pain after laparoscopic cholecystectomy.
Patients and methods: In Qena university hospital, this prospective randomized comparative study was conducted, 80 patients were scheduled to elective laparoscopic cholecystectomy. Group intraperitoneal"IP" lidocaine (40 patients) received 200 ml saline containing 200 mg 2%lidocaine immediately after pneumoperitoneum, the total solution was sprayed on the upper surface of the liver, right subdiaphragmatic space and around the cholecystectomy site. Group indomethacin (40 patients) received two 100 mg indomethacin rectal suppositories 2 hours prior to surgery.
Results: VAS score was significantly lower in indomethacine group ( p value =0.03)over the 24 hours postoperative . The postoperative pethidine requirements were significant lower in group indomethacin mean (34±11.4 mg). Postoperative nausea and vomiting were less in group indomethacin with no statistically significant difference.
Conclusion: preoperative rectal indomethacin suppositories decrease postoperative pain scores and analgesics requirements without producing side effects comparing to IP lidocaine in LC.
Clinical trail .gov . ID:NCT04964180
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
114
125
https://svuijm.journals.ekb.eg/article_207391_76df2f5f9b82d9c7b080a5b94314bde3.pdf
dx.doi.org/10.21608/svuijm.2021.101821.1235
Intratympanic Injections of steroids For Treatment of sudden sensorineural hearing loss: Does the frequency of injections affect the outcome?
Usama
taya
Department of Otorhinolaryngology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mohamed Wael Mohamed
Mustafa
Department of Otorhinolaryngology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Shaimaa Asaad
Fawzy
Department of Otorhinolaryngology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Zaki
Aref
Department of Otorhinolaryngology, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Sudden sensory neural hearing loss (SSNHL) is an ENT emergency which is defined as a loss of hearing of 30 dB or more, over at least 3 successive frequencies, that develops within 3 days in most cases it is unilateral and the most age group to be affected are 40s and 50s in most cases the cause is not known and called idiopathic sensory neural hearing loss. pure tone audiometry is done to confirm the hearing loss, history, examination, MRI and blood tests to exclude serious underlying causes . Objective: to compare between the efficacy of four versus two intra tympanic injection of steroid for treatment of sudden idiopathic sensory neural hearing loss. Patients and Methods. During the time frame from February 2020 to January 2021 a thirty patients (15 males and 15 females) with ISSNHL who visited our otorhinolaryngology department, Qena university hospital. were merged with intra tympanic steroid injection for treatment of sudden sensory neural hearing loss. The ages rang was from 40 to 69. Results: According to our statistical analysis and data, hearing improvement after 4 intra tympanic injection is better than 2 injections with a p value is 0.000. Conclusion: Injection of 4 times intra tympanic injection of steroid appears to be more effective than two times of injection.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
126
132
https://svuijm.journals.ekb.eg/article_162954_7d07abf34533ffbc1939f78806c7f925.pdf
dx.doi.org/10.21608/svuijm.2021.68849.1140
Use of Lung Ultrasound with Tissue Doppler Echocardiography to Follow up Cardiovascular State of Haemodialysis Patient
AbdelKader A.
Hashim
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt
author
Alaa
Rashad
Department of Chest diseases and tuberculosis, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ahmed G.
Bakry
Department of Internal Medicine, Cardiology Div., Faculty of Medicine, South Valley University, Qena, Egypt
author
Ghada M.
Abdelrazek
Department of Radio diagnosis, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mustafa Abdullah
Ahmed
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Chronic hypervolemia is the main cause of cardiovascular complications in haemodialysis patients. Objectives: We aimed to study the effect of lung ultrasound-guided dry weight reduction strategy on the cardiovascular state of hypertensive haemodialysis patients. Patients and Methods: We carried out a single-blind two-arm randomized trial on 50 hypertensive haemodialysis patients in Qena University Hospital dialysis centre over 8 weeks from 1/11/2020 to 1/1/2021. Patients were divided into usual care group (control arm) and active group(study arm). In study group, dry weight reduction was assessed weekly by lung ultrasonography guided by the total number of B-lines, before the midweek session of haemodialysis. In the control group, dry weight probing was done according to clinical criteria. To assess outcomes, we compared the clinical and echocardiographic improvement in both groups including full clinical assessment, etc at baseline and at the study end. Results: In study group, dry weight was significantly reduced in comparison with the control group (−0.41 ± 0.32 vs. 0.04 ± 0.09 kg; P < 0.001), resulting in a statistically significant reduction in systolic and diastolic blood pressures (P < 0.001). Furthermore, a statistically significant reduction in echocardiographic indices of cardiac chambers dimensions occurred in study group, in addition to improvement of the diastolic function of both ventricles. Conclusion: Ultrafiltration based on assessment of fluid status using lung ultrasound dry weight reduction is better than that based on conventional method regarding both clinical and echocardiographic parameters.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
133
145
https://svuijm.journals.ekb.eg/article_149089_c64842cf1d224bdfb3f95f509d1c865a.pdf
dx.doi.org/10.21608/svuijm.2021.62889.1084
Norepinephrine versus Ephedrine to maintain arterial blood pressure during spinal anesthesia for cesarean section
Abdel-baset T.
Ahmed
Medical Anesthesiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Hatem S.
Mohammed
Medical Anesthesiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mohammed A.
Soliman
Medical Anesthesiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ahmed Fathy
Abdellatif
Medical Anesthesiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Spinal anesthesia is recommended for elective cesarean sections, but maternal hypotension by may occur, resulting in severe maternal complications. To avoid spinal hypotension, many methods were attempted; fluid loading, vasopressors, or combination of both.
Objectives: Our study aimed to compare administration of intermittent i.v. boluses of norepinephrine and ephedrine to guard against hypotensive effect of spinal anesthesia during delivery.
Patients and methods: This study was conducted at Qena University Hospitals, sixty cases undergoing elective cesarean section under spinal anesthesia were enrolled. They were randomly allocated to two equal groups, group N received prophylactic i.v. bolus of norepinephrine 5 μg, group E received prophylactic bolus of i.v. ephedrine 10mg immediately after intrathecal block. Incidence of hypotension and the numbers of the boluses of vasopressors used were recorded and considered as primary outcomes, maternal complication during the surgery as secondary outcomes.
Results: According to SBP, DBP, MAP there was significant lower values in groupE compared with group N. The mean number of boluses of vasopressors used during spinal anesthesia was significantly lower in Group N (2.2 vs. 5.8, P = 0.001). the mean number of hypotension episodes was also significantly lower in Group N (2.5 vs. 5.33, P = 0.001). Regarding operative maternal complications, Group N had a significantly lower nausea(16.7% vs. 66.7%, p=.001) vomiting (60% vs. 16.7%, p=0.001). shivering (23.3% vs. 0%, p=0.001).
Conclusion: Norepinephrine can be used as an alternative vasopressor to maintain maternal blood pressure during spinal anesthesia for cesarean delivery, with lower incidence of maternal complication.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
146
154
https://svuijm.journals.ekb.eg/article_168847_9ec34ae510b3941cff24725b6e184d04.pdf
dx.doi.org/10.21608/svuijm.2021.70977.1159
A Comparative Study between Coblation Adenoidectomy and Conventional Adenoidectomy
Zaki F.
Aref
Department of Otorhinolaryngology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Badawy S.
Badawy
Department of Otorhinolaryngology, Faculty of Medicine, Luxor University, Egypt
author
Ahmed Gaber
Abdelraheem
Department of Otorhinolaryngology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Esraa A.
Mohamed
Department of Otorhinolaryngology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Usama
Taya
Department of Otorhinolaryngology, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Back ground: the classic surgical technique performed with an adenoid curette or an adenotome has recently developed by the introduction of the endoscopic sinus surgery Objectives: to compare the safety and efficacy of coblation adenoidectomy versus conventional curettage adenoidectomy. Patients and methods: This study was conducted on 50 patients who came to outpatient clinics in the Otolaryngology department, of age group between 4-14 years with adenoids hypertrophy from February 2019 to February 2020. Results: results revealed that the mean time of operation, it was11.1 ± 1.5 min in group A, but was 14.2 ± 1.8 min in group B, with statistical significance relationship P=000. Regarding the mean of Intra operative blood loss, it was32.4±3.2 ml in group A, but was 2.5±1.2 ml in group B, with statistical significance relationship P=000. Conclusion: The advent of endoscopes made a significant impact in adenoidectomy. Endoscopic assisted adenoidectomy is a natural progression of this technology to allow a more complete adenoidectomy. From this we concluded that the overall advantages of coblation adenoidectomy, compared with cold curettage, are the decrease in intra and post-operative bleeding, better safety, precision of adenoid removal and less injury to adjacent tissues.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
155
163
https://svuijm.journals.ekb.eg/article_121349_704c7d7ee9ad57adf7a9bc835e69f708.pdf
dx.doi.org/10.21608/svuijm.2020.48334.1028
Diagnostic value of MRI in ovarian masses detection and characterization
Ahmed Samir
Kamel
Diagnostic Radiology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Mohamed Tharwat Mahmoud
Solyman
Diagnostic Radiology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Ahmed
Abdelhafez
Obstetrics and Gynecology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Nahla Mohammed
Ali
Diagnostic Radiology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
text
article
2022
eng
Background: Ovarian masses are late symptomatic so early detection and characterization of the ovarian neoplasm is very important for adequate therapeutic procedure, this starts from the physical examination to the imaging technique and laboratory investigations. MRI show high contrast resolution so MRI gives proper detection and differentiation of benign and malignant ovarian masses by the utility of different sequences like conventional MRI imaging, To obtain anatomical data and study the different signal intensities of the ovarian lesions T1 and T2 sequences are needed, T1 SPIR to assess the hemorrhagic and fatty areas, MRI with Gadolinium enhance the MRI ability to differentiate between benign and malignant ovarian masses, tumor staging and follow up.Diffusion-weighted imaging and proton MRI spectroscopy are a functional MRI sequences increase MRI sensitivity and specificity in diagnosis of ovarian lesions. Conclusion: MRI is considered solving problem imaging modality in early determine the site and characterize the ovarian masses, also it is helpful at ovarian tumor staging.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
164
173
https://svuijm.journals.ekb.eg/article_210044_3efa46efb44bb4d36285396741f2a73c.pdf
dx.doi.org/10.21608/svuijm.2021.110650.1253
Role of MRI Diffusion in differentiating of benign and malignant ovarian masses
Ahmed Samir
Kamel
Diagnostic Radiology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Mohammad Tharwat Mahmoud
Solyman
Diagnostic Radiology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Ahmed Tageldin
Abdelhafez
Obstetrics and Gynecology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Nahla Mohammed
Ali
Diagnostic Radiology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
text
article
2022
eng
Background: Ovarian masses are more common findings incidentally detected in symptomatic patients in every day work, to characterize them MRI is a modality of choice due to its high tissue contrast so MRI has high sensitivity, specificity and accuracy.
Objectives: Assessment of role of MRI diffusion in differentiating of benign and malignant ovarian masses.
Patients and method: Study was carried out on 60 female cases presented by ovarian masses referred from the OB/GYN out clinic and in patients between September 2019 and September 2020. The study was done in MRI unit, Diagnostic Radiology Department at Sohag Faculty of Medicine during the period from September 2019 to September 2020. For every patient a written consent was taken, patient’s clinical data, pelvi-abdominal US, laboratory investigations and pelvis MRI were done.
Results: 46 cases (76.7%) had benign ovarian lesions and 14 cases (23.3%) had malignant ovarian lesions. All the malignant cases (100%) show restriction at DWI while only 11 benign cases (23.9%) show restriction at DWI. The mean ADC was 1.76x10-3 mm2/s, with a range from 0.5x10-3 mm2/s to 3x10-3 mm2/s (P value <0.001 (HS). The mean ADC was higher among benign cases (2.082x10-3 mm2/s) compared to malignant ones (0.707x10-3 mm2/s), ADC cut-off point is 0.895x10-3 mm2/s, with a sensitivity of 89.1% and a specificity of 92.9% with P value <0.001.
Conclusion: DWI and ADC value increases the accuracy of MRI to discriminate between benign and malignant lesions. Cut-off value was 0.89x10-3 mm2/s to differentiate between benign and malignant ovarian masses.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
174
187
https://svuijm.journals.ekb.eg/article_210142_ee09ca43ba5e12a94d671fd426687fb2.pdf
dx.doi.org/10.21608/svuijm.2021.110653.1254
Soft versus Conventional Protocol in Ovarian Stimulation in Intracytoplasmic Sperm Injection Cycles for Poor Responders: A randomized clinical trial
Abd El-Naser Abd El-Gaber
Ali
Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ahmed Hashem
Abdellah
Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ahmed Hamdy
Mohammed
Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Hazem Hashim
Ahmed
Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Mild(soft, minimal) protocols have been proposed as an alternative to the classical protocols , a controlled ovarian stimulation is defined as “soft” either when (a) Gonadotrophins (Gn) are given at a lower dose and/or for a short period together with a GnRH-antagonist, or when (b) oral compounds (e.g. anti-estrogens) are used alone or in combination with Gn and GnRH-antagonists. Objectives: The aim of this study was to compare between soft and conventional protocol in ovarian stimulation for poor responders women undergoing Intracytoplasmic sperm injection procedure(ICSI). Patients and methods: This study is A randomized clinical trial, carried out at Assisted Reproduction Unit, Qena University hospital, South Valley University, Egypt, on 120poor responder women undergoing ICSI divided randomly into two groups:(Group 1): included 60 patients received soft ovarian stimulation protocol, (Group 2): included 60 patients received conventional ovarian stimulation protocol.
Results: In comparison between the two groups regarding cancellation rate ,chemical and clinical pregnancy were comparable with no statistically significance between soft group and conventional group. Conclusion: This analysis presents strong evidence in favor of soft stimulation in intracytoplasmic sperm injection cycles for poor responders, which therefore should currently be considered a treatment of choice for patients requiring intracytoplasmic sperm injection cycles for poor responder's treatment.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
188
196
https://svuijm.journals.ekb.eg/article_210157_479ff5722c88ac12c76d3ec78c807040.pdf
dx.doi.org/10.21608/svuijm.2021.108815.1249
The effect of intraoperative magnesium sulfate and ketamine infusion on post-operative pain in open gynecological surgeries
Gad Sayd
Gad
Department of Anaesthesia, ICU and pain management, Faculty of Medicine, South Valley University,Qena, Egypt
author
Asmaa Sabri
Abo-Elmaged
Department of Anaesthesia, ICU and pain management, Faculty of Medicine, South Valley University,Qena, Egypt
author
Ahmed Yosof
Ahmed
Department of Anaesthesia, ICU and pain management, Faculty of Medicine, South Valley University,Qena, Egypt
author
Mahmoud Mohammed
Ahmed
Department of Anaesthesia, ICU and pain management, Faculty of Medicine, South Valley University,Qena, Egypt
author
text
article
2022
eng
Background: besides an opioid analgesic, multimodal analgesia using a non-opioid analgesic, in atrial to decrease opioid use and to increase postoperative pain control.
Objectives: To compare the effect of intra-operative infusion of ketamine and magnesium sulphate in open gynaecological surgeries on post-operative pain, total morphine consumption, post-operative nausea, and vomiting in Qena University Hospitals.
Patients and methods: A prospective study. Conducted in Qena University Hospital, South Valley University, Qena, Egypt. The study was conducted on fifty patients (ASA I or II) scheduled for open gynaecological surgeries under general anaesthesia: group A: Ketamine (0.2 mg/ kg) bolus than the continuous supply of ketamine (0.05 mg/kg/h), group B: Magnesium sulphate (50mg/ kg) bolus and followed by continuous infusion of magnesium sulfate(10mg/kg /h).
Results: the visual analogue scale was found to be significantly higher in group B compared to group A in 2, 4, and 8 hrs time intervals. The mean opioid (Morphine/Pethidine) consumption doses over 24h were lower in group A compared to group B. There is no significant difference regarding adverse events between the two studied groups.
Conclusion: Intraoperative magnesium sulfate and ketamine infusion in patients exposed to gynecological surgeries with general anesthesia could and decreased the post-operative opioid requirement. Ketamine showed a significant preemptive analgesic effect compared to MgSO4 at 2 and 8 h postoperatively. VAS was significantly lowered in Ketamine than MgSO4.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
197
203
https://svuijm.journals.ekb.eg/article_148424_49188d4f40674466f3d9494c8337c892.pdf
dx.doi.org/10.21608/svuijm.2021.62417.1080
Evaluation of the outcomes of laparoscopic splenectomy in non-traumatic pathological splenic disorders
Mohamed Yousef
A.
Department of General Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Hamdy Mohamed
Hussein
Department of General Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Mohamed Ahmed
Marzouk
Department of General Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Nezar Abdel Rouf
Abo-Halawa
Department of General Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
text
article
2022
eng
Background: Indications for laparoscopic splenectomy are the same as those of open splenectomy, except for the trauma cases, where the role of laparoscopy is still debatable. More studies are needed to determine the real value of laparoscopy in massive splenomegaly.
Objectives: The aim of the work is evaluation of the outcomes, safety and efficacy of laparoscopic splenectomy in non-traumatic splenic disorders.
Patients and methods: This prospective study conducted on patients with hematological disorders indicated for splenectomy for one year.
Results: We operated 20 patients of laparoscopic splenectomy, 70% were females, their mean of age by years were 18.9 ± 9.1. No post-operative complications the mean of operation time by hours was3.2 ± 0.7, while the mean of hospital stay was 2.3 ± 0.2 days. The total intra-operative blood loss was about 50–600 ml.
Conclusion: Laparoscopic splenectomy for elective operations of the spleen is a safe method associated with a lower risk of peri-operative complications, less mortality and morbidity.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
204
209
https://svuijm.journals.ekb.eg/article_163666_be452816914bab2f627d142f83fa55b1.pdf
dx.doi.org/10.21608/svuijm.2021.67779.1134
Ability of Short wavelength automated perimetry to detect visual field changes in diabetic patients
Mohamed Ateto
Hamed
Ophthalmology Department, Faculty of Medicine, Luxor University, Luxor, Egypt
author
Ahmed Hasan
Aldghaimy
Ophthalmology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Hany Omer
Elsedfy
Ophthalmology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Ayat Yosef
Mohamed
Ophthalmology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Globally, diabetes-related eye illness is the primary cause of visual impairment due to cataracts or retinopathy. The two most used visual field testing modalities in clinical practice are standard automated white-on-white (W-W) perimetry (SAP) and short wave length automated perimetry (SWAP). Objectives: To compare the value of short wave length automated perimetry SWAP (blue on yellow in contrast) to standard automated perimetry SAP in detecting changes in retinal sensitivity in diabetic individuals with or without retinopathy. Patients and methods: Forty eyes of forty patients divided into two groups, group (A) diabetic patients (20 eyes) without diabetic retinopathy and group (B) diabetic patients (20 eyes) with early diabetic retinopathy. The perimetry was done for all patients into two perimetry examination. First visit was for SAP and second visit was for SWAP. Results: In SAP, group II's MD (mean deviation) was considerably lower than group I's (P = 0.003). In SWAP, the MD in group II was considerably lower than in group I (P = 0.001). MD was substantially lower in SWAP than SAP in group I (P = 0.00009). In group II, the same results were obtained. Conclusions: In terms of distinction, the SWAP approach proved more sensitive and informative than the SAP technique.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
210
218
https://svuijm.journals.ekb.eg/article_210256_4c68a8538ffa998d7e6ad62e34b3ce38.pdf
dx.doi.org/10.21608/svuijm.2021.89566.1205
Anterior segment optical coherence tomography assessment of corneal thickness before and after primary pterygium surgery
Ahmed Hasan
Aldghaimy
Department of Ophthalmology, Faculty of Medicine, South Valley University , Qena , Egypt
author
Ossama AbdEl meneim
El_sagheir
Department of Ophthalmology, Faculty of Medicine, South Valley University , Qena , Egypt
author
Reham Mostafa
Mohamed
Department of Ophthalmology, Faculty of Medicine, South Valley University , Qena , Egypt
author
Mohamed Ateto
Hamed
Department of Ophthalmology, Faculty of Medicine, Luxor University , Luxor, Egypt
author
text
article
2022
eng
Background: Anterior Segment Optical Coherence Tomography is the key tool to assess the corneal thickness. Pterygium is one of the most common ocular surface diseases. Our research about evaluation one of the corneal and conjunctival disorders with anterior segment OCT Objectives: Main purpose for our study is to evaluate corneal thickness before and after pterygium excision by anterior segment OCT. Patient and Methods: This study was performed between September 2020 and April 2021. Cases were recruited from outpatient clinic and inpatient wards of ophthalmology department in Qena University hospital. In each patient one eye was included in the study. Results: Our study included 40 patients of both sexes and evaluation of corneal thickness revealed that thickness preoperative is 862.2 ± 93.4 µm and one week post operative is 480.1± 57.9 µm and one month post operative is 500.4 ± 56.1µm .. Mean of corneal thickness pre-operative /post-operative one week was 382.05 ± 100.2 with statically significant relationship with P value =0.00.Mean of corneal thickness pre-operative /postoperative one month was 361.67 ± 102.6 with statically significant relationship P value =0.00.Mean of corneal thickness one month post-operative /one week post-operative 20.37± 24. 5 with statically significant relationship P value 0.00. Conclusion: This study revealed that corneal thickness decreased after pterygium surgery and after one week from surgery the epithelium completely healed to reach average normal thickness which is also affected by aging and some diseases.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
219
225
https://svuijm.journals.ekb.eg/article_210305_464287a11dbb8115293a9abb3da7cbf9.pdf
dx.doi.org/10.21608/svuijm.2021.86179.1197
Potential Reno-Protective Effect of Dexmedetomidine Versus N. Acetylcysteine Among Patients Undergoing Cardiac Surgery
Mohamed Elzouk
Oraby
Department of Anesthesia, ICU and Pain management, Faculty of Medicine, South Valley University, Qena, Egypt
author
Salah Mostafa
Asida
Department of Anesthesia, ICU and Pain management, Faculty of Medicine, South Valley University, Qena, Egypt
author
Hatem Saber
Mohamed
Department of Anesthesia, ICU and Pain management, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ahmed Yosof Ahmed
Abdel Zaher
Department of Anesthesia, ICU and Pain management, Faculty of Medicine, South Valley University, Qena, Egypt
author
Abdallah Elaiw Mohamed
Ali
Department of Clinical and Chemical Pathology, ICU and Pain management, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Acute kidney injury (AKI) is one of the severe complications after cardiac surgeries, raising morbidities and mortalities. Objectives: The study aimed to compare the potential reno-protective effect of continuous I.V infusion of Dexmedetomidine (DEX) and N-Acetylcysteine (NAC) among cases undergoing Cardiac surgeries. Patients and Methods: This randomized, double-blind, placebo-controlled trial was done at Qena University Hospitals and Sohag Cardiac Institute in period between October 2019 to October 2021, including 90 cases listed for elective on pump open-heart surgeries. Results: Regarding Urine Output(UOP), the DEX group showed a significantly higher UOP value than both NAC and placebo groups at day 1 postoperatively. Still on day 2 postoperatively, the DEX group showed a statistically significant higher UOP value than the placebo group only. Also, there were non-statistically significant differences between pre-operative and postoperative values in each group (between basal and final values). Regarding urinaryNeutrophil Gelatinase-associated Lipocalin (NGAL), there were non-statistically significant differences between groups at baseline, but the DEX group showed a significantly lower NGAL values than the placebo group at T1 and T2 postoperatively. Also, there were statistically significant differences between pre-operative and postoperative values in all groups.DEX group showed significantly lower postoperative AKI incidencethan placebo group. Conclusion: DEX could have a more reno-protective effect among patients undergoing cardiac surgery than N-acetylcysteine or placebo. This was demonstrated by lower urinary NGAL level, raised UOP, and lower postoperative AKI among cases treated with DEX.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
226
239
https://svuijm.journals.ekb.eg/article_210463_7c93cf8ab0c529498b0f321dcbca7ac3.pdf
dx.doi.org/10.21608/svuijm.2021.105368.1240
Immunohistochemical Expression of Caspase-3 in Colorectal Carcinoma
Sheren FM
Ahmed
Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt.
author
Christeen NB
Bernaba
Department of Pathology, Oncology Sohag Center, Sohag ,Egypt
author
Eman M.S.
Muhammad
Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt.
author
text
article
2022
eng
Background: Apoptosis is an important factor in the development of tumors especially colorectal carcinomas (CRC). Caspase-3 is considered an ideal marker for measuring apoptosis in these tumors.
Objectives: To evaluate the Caspase-3 expression and its correlation with the available clinicopathological criteria in patients with CRC.
Patients and methods: Fifty cases of CRC removed by colectomy were enrolled in this study. Caspase-3 expression was evaluated by immunohistochemistry (IHC) using streptavidin-biotin-technique.
Results: Caspase-3 appeared as brownish nuclear staining and was expressed in all cases of CRCs. Caspase-3 showed positive significant correlation with age (p= 0.046), histological variant (p= 0.02),and negative correlation with tumor grade (p < 0.001), depth of tumor invasion; T stage (p < 0.001) and lymph node status(p < 0.001).
Conclusion: High expression of Caspase-3 in CRC patients related to favorable clinicopathological features and could be a potential independent prognostic factor. Caspase-3 may act as a tumor suppressor in CRC.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
240
251
https://svuijm.journals.ekb.eg/article_212147_1f2a20e50ae5e186601ef43c2d899b22.pdf
dx.doi.org/10.21608/svuijm.2022.108052.1246
The pattern of systemic inflammatory markers response in neonatal sepsis
Reham
Ashour
Department of Chemical and Clinical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Zainab
Waael
Department of Chemical and Clinical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Nagwan I.
Rashwan
Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Hanan Mahmoud
Fayed
Department of Chemical and Clinical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt.
author
text
article
2022
eng
Background: Early diagnosis of sepsis is a clinical challenge as the clinical symptoms are subtle, late, and nonspecific. Minimum of 48 hours is required for the earliest result of blood culture, and it can be negative despite clinical signs of sepsis. Delaying the treatment leads to an increase in mortality. Thus, it is crucial to diagnose neonatal sepsis early to initiate treatment as early as possible. Aims: To assess the pattern of systemic peripheral inflammatory response markers as early predictors for the diagnosis of sepsis in neonates. Patients and methods: This was a case-control study conducted on one hundred cases suspected to have with neonatal sepsis (NS), in addition to other fifty neonates with no suspicion of having NS. All the subjects underwent thorough history taking, complete clinical evaluations, and laboratory investigations for a systemic inflammatory response. Results: The overall patients' mean ages were (14.12 ±7.12 days), 70% were male and 30% were females. When compared to the control group we found elevated immature to total neutrophil (IT) ratio, CRP, ESR, TLC, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) to have significant diagnostic value for NS, in addition to hematological indices and scores. Conclusion: The IT ratio is the best single index for NS diagnosis having a comparable significance as CRP and ESR, however, the IT ratio was superior to WBC count in the sensitivity, specificity, the positive predictive value, and the negative predictive value.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
252
260
https://svuijm.journals.ekb.eg/article_156920_493fa342a7d7af8be68e62840d693a4e.pdf
dx.doi.org/10.21608/svuijm.2021.67088.1124
Left Ventricular Dysfunction in Prediabetic Patients: A review article
Mohamed A.
Elsenbsy
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt & Internal Medicine Department ,Arabian Gulf University(AGU),Bahrain
author
Ahlam M.
Sabra
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Abdulla Eliaw Mohamed
Ali
Department of Clinical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Gehad Osama Fawzy
Sayed
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Hossam Eldin M.
Mahmoud
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.
author
text
article
2022
eng
Background: Prediabetes is a common condition that indicates a state between normal glucose metabolism and diabetes. This is considered a dangerous condition because of the high risk of developing diabetes. A recent study in Europe shows that visually impaired fasting increases glucose and impaired glucose tolerance. prevalence of impaired fasting glucose (IFG) levels range from approximately 3%to 5% in the 20 -44 age group and approximately 20% to 30% in the 65-74 age group. Evidence suggesting a link between the risk of neuropathy, nephropathy, early retinopathy, and macrovascular disease and prediabetes. Prediabetes is associated with a 20% increased risk of cardiovascular disease compared to normoglycemic individuals. Several studies have established systolic and diastolic left ventricular dysfunction in prediabetic patients. We aimed to highlight left ventricular dysfunction in Prediabetic patients and to describe the possible underlying mechanisms of this association. Conclusion : There is a significant association between left ventricular systolic and diastolic dysfunction and prediabetes. The defects underlying prediabetes which include insulin resistance, metabolic syndrome, dyslipidemia, and inflammation, have been implicated to predispose diabetic patients to increased risk of developing ventricular dysfunction.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
261
267
https://svuijm.journals.ekb.eg/article_152346_d5e517615af652be974b2467e4f3db97.pdf
dx.doi.org/10.21608/svuijm.2021.63389.1088
Risk Factors for Diabetic Ketoacidosis In Sohag University Hospitals
MOHAMED
Eid
Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag 82545, Egypt.
author
Imran Saber
Mohammad
Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag 82545, Egypt.
author
Adel Abdel-Aziz
El-Sayed
Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag 82545, Egypt.
author
Hamdy Saad
Mohamed
Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag 82545, Egypt.
author
text
article
2022
eng
Background: Diabetic ketoacidosis (DKA) is considered one of the pathological developments resulting from diabetes mellitus (DM), which threatens the patient's life. In Egypt, many factors participated in DKA prevalence, which increases the need for further deep studies.
Objectives: The current study aimed to measure and evaluate clinical profiles, the possible risk factors for DKA in Sohag Governorate, Egypt.
Patients and Methods: 60 patients diagnosed with DKA were recruited for six months between September 2018 and March 2019. The medical history and clinical investigations were applied to all participants. Data were collected and analyzed.
Results: The participants had a mean age of 32.76±18.8 years, and 62 % were females. Most of the patients had a medical history of DM, and only 11.7% of them had a recent diagnosis. 55% of DKA patients had either respiratory tract or urinary tract infections (26.6% and 16,6%, respectively), where noncompliance for treatment was reported in 50% of cases. Lack of awareness about the DKA disease and its complication was reported in 45% of patients. Other comorbidities such as stroke (6.7%), myocardial infarction (MI) (8.3%), and acute pancreatitis (3.3%) were reported, as well.
Conclusion: Many of the DKA patients from Sohag University Hospital, Sohag, Egypt, lack awareness about the disease and its risk factors. The major risk factors for DKA were either infection or less commitment to the medical regimens. More efforts should be paid to accommodate the health education weakness of diabetes and DKA risk factors.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
268
272
https://svuijm.journals.ekb.eg/article_212788_7d77509565da5d9a3b1385a6047f9058.pdf
dx.doi.org/10.21608/svuijm.2022.111031.1255
Agonist hold Antagonist Protocol versus Antagonist Protocol in Intracytoplasmic Sperm Injection for Infertile Patients with Polycystic Ovary Syndrome
Hazem H.
Ahmed
Department of Obstetrics and Gynecology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mahmoud I
Alrashidy
Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University (Assiut Branch), Assiut, Egypt
author
Osama A. M.
Ali
Department of Obstetrics and Gynecology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ahmed H.
Abdellah
Department of Obstetrics and Gynecology, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Polycystic Ovary Syndrome (PCOS) is currently thought to emerge from a complex interaction of genetic and environmental traits.PolycysticOvarySyndrome is the most common endocrinopathy among reproductive-aged women
Objectives: The aim of this study was to compare between agonist hold antagonist protocol and antagonist protocol in ICSI for Infertile patients with PCOsas regard the number of oocytes retrieved, fertilization rate, implantation rate and clinical pregnancy rate.
Patients and methods: This was a prospective comparative study, which was conducted at Assisted Reproduction Unit at Qena University Hospital.This work had been conducted on infertile women with PCOS undergoing ICSI in ART unit in obstetrics and gynecology department, Qena University hospital from January 2019 to June 2020.
Results: The number of implanted embryos was significantly higher in agonist hold antagonist protocol group compared to antagonist protocol group (p < 0.001).Also,clinical pregnancy was found to be significantly higher inagonist hold antagonist protocol group compared to antagonist protocol group (p=0.009). On the other hand, prevalence of OHSS was significantly higher in antagonist protocol group compared to agonist hold antagonist protocol group (p=0.023).There was no statistically significant difference between the two groups regarding β-HCG (p>0.05).
Conclusion: GnRH agonistholdantagonist may be a preferred protocol for PCOS patients treated with ICSI in view of the reduction of the risk of OHSS, the shorter stimulation time and better pregnancy outcome.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
273
279
https://svuijm.journals.ekb.eg/article_212907_9a03874612c94671f45b160fa8d22c58.pdf
dx.doi.org/10.21608/svuijm.2022.113449.1259
The effect of different types of laparoscopic bariatric procedures on type 2 diabetic obese patients
Mohamed Yousef
Ahmed
Department of General Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Ahmed Mohamed
Safy
Department of General Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Wael Nabil
Abdel-slam
Department of General Surgery, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
author
Hamdy Mohammed
Hussein
Department of General Surgery, Faculty of Medicine, Luxor University, Luxor, Egypt
author
text
article
2022
eng
Background: The rising global incidence and prevalence of type II diabetes (T2DM) has paralleled the rise in obesity. Bariatric surgery is currently the most effective treatment for obesity compared to maximal medical and lifestyle management.
Objectives: This work aimed to compare the efficacy and safety of LSG (group 1), (LRYGB) (group 2) and (MGB) (group 3) for T2DM obese patients.
Patients and Methods: A randomized prospective clinical study for 225 patients with morbid obesity (BMI 35 kg/m2 or more with T2DM) treated by laparoscopic sleeve gastrectomy (LSG),laparoscopic Roux-en-Y gastric bypass(LRYGB) and mini gastric bypass (MGB),(75 patients in each group) conducted in Qena and Alexandria university hospitals from March 2019 to September 2020.The primary outcome was complete remission of type 2 diabetes with hyperglycemia control, (HbA1c <6 %). The secondary outcome was weight loss is by calculating the percentage of excess weight loss (% EWL)
Results: There was statistically significant difference between the three studied groups regarding time of surgery (96.5 ± 17.6, 107.3 ± 19.4, and 106.6 ± 15.8 among group 1, 2, and 3respectively; P-value < 0.05). There was no statistically significant difference between the three studied groups regarding hospital staying duration and postoperative complication. There was no statistically significant difference between the three studied groups regarding HbA1C post-operative.
Conclusion: Metabolic surgery has emerged as the single most effective treatment option for T2DM and obesity. There is a potential superiority of the LRYGB and MGB over the LSG in obtaining diabetes remission.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
280
288
https://svuijm.journals.ekb.eg/article_213264_56b666b51927fb5f36c058933f0788fd.pdf
dx.doi.org/10.21608/svuijm.2022.114993.1263
Assessment of Hormonal Contraceptives Use Among Early Married Women in Qena City
Asmaa A.
Sayed
Department of Public Health and Community Medicine, Faculty of Medicine, South Valley University
, Qena, Egypt.
author
Ahmed M.M.
Hany
Department of Public health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
author
Mahmoud S.
Iwes
Department of Obstetrics and Gynecology, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Marriage in young age is a very common problem in Egypt. According to Central agency for public mobilization and statistics in Egypt, Qena is the first government in early marriage by 12.8 per 1000 person. This indicates the great reproductive problem that faces women like unintended pregnancy and maternal mortality.
Objectives: Assessment effect of marriage age on contraceptives behaviors. Also, to identify other factors that can affect using of hormonal contraception methods like education, husband opinion about family planning idea and socioeconomic level.
Patients and methods: At family planning clinics of five primary health care units in Qena city this cross-sectional study was conducted on 400 married females in reproductive aged 15:49 years to detect relation between marriage before legal age (18 years) and practicing family planning. There are two groups, female married before 18 years and that married at or after 18 years. A structured questionnaire was used.
Results: There is a significant relation between marriage age and hormonal contraceptives use, about 73.2% of female included in our study use contraception methods and married after age of eighteen (p- value = 0.001). According to logistic regression analysis husband opinion is the most contributing factor associated with use of Contraception (p- value <0.0001) while the least contributing factor is husband education (P-value=0.064).
Conclusion: Using of hormonal contraception was low among females married before age of eighteen so their family size is higher. Education plays a vital role in practicing family planning.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
289
297
https://svuijm.journals.ekb.eg/article_213621_803ab465b62a4ea31956493e1e6abddb.pdf
dx.doi.org/10.21608/svuijm.2022.114291.1261
Role of MRI Spectroscopy in diagnosis of brain Glioma: A Cross-Sectional Study
Ahmed
Okasha
Department of Diagnostic and Intervention Radiology, Faculty of Medicine, South Valley University, Qena 83523, Egypt
author
Ali R.
Hamdan
Department of Neurosurgery, Faculty of Medicine, South Valley University, Qena 83523, Egypt
author
text
article
2022
eng
Background: Glioma a common type of the brain tumor, which originates in the glial cells that surround and support neurons in the brain, including astrocytes, oligodendrocytes and ependymalcells.
Objectives: This study is aiming to investigate the role of MRS in patients in diagnosis of brain glioma.
Patients and methods: The study was designed as a cross-sectional study recruit 30 patients, who were referred to the Radio-diagnosis Department of South Valley University Hospitals for suspected glioma from neurosurgery department during the period from February 2018 to Aug 2021 the study protocol was approved by the local ethics committee of South valley University hospitals (Ref No Code Ms-4–2018, Date of approval 10–02-2018). and it was approved by the local Research Ethics Committee of our hospital.
Results: The study included 30 patients with age ranged from six to 72 years old.
The lesions within the repetitive tumor group had essentially higher Cho/Cr ratios than those within the radiation damage group (p < 0.0001; SE, 0.18), and these, also, had vitally higher Cho/Cr proportions than the typical white matter of 6 patients (p = 0.0003; SE, 0.09). In differentiating tumor versus non-tumor lesions, the sensitivity and specificity of Cho/NAA ratio greater than 2.0 was 96% and 70%, respectively. For ratios higher than 2.5, the sensitivity and specificity to detect tumors was 97% and 86%, respectively.
Conclusion: MRS examination was greatly beneficial in differentiating neoplastic from non-neoplastic lesions and decrease for stereotactic brain biopsy. However, further studies are required to confirm the current evidence.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
298
304
https://svuijm.journals.ekb.eg/article_215158_ac82a6fd722012e98477e86291bb82df.pdf
dx.doi.org/10.21608/svuijm.2022.114633.1262
Role Of Contrast-Enhanced Magnetic Resonance Imaging and Diffusion- Weighted Magnetic Resonance Imaging In evaluation of the pancreatic Lesions
Ahmed
Okasha
Diagnostic Radiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ghada Mohamed
Abd-Elrazek
Diagnostic Radiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mohamed Ahmed
Negm
Pediatric Surgery Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Shimaa Mohamed Ahmed
Abd-Elghani
Diagnostic Radiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Pancreatic tumor is a very lethal human tumors that needs earlier diagnosing. US, CT and MRI are various imaging methods employed to diagnose of pancreatic masses. Contrast-enhanced MRI (CE-MRI) Diffusion-weighted magnetic resonance imaging [DW-MRI] are progressively utilized or detection and characterization of various pancreatic lesions. Objectives:The current study aimed to evaluate the utility of contrast-enhanced MRI (CE-MRI) and [DW-MRI] in characterizations of pancreatic lesions. Patients and methods: This work was prospective study performed at The Department of Radiology, Qena University Hospitals, with cases with pancreatic lesions over an interval of 12 months who previously discovered by other imaging modalities that desire more characterizations via MRI. Results: The DWI imaging sensitivity was 100%, specificity was 100%, NPV was 100% and PPV was 100% with accuracy of 100% for detecting benign and malignant tumors.ADC value was significant at cutoff value .
Conclusion: We concluded that CE-MRI and DW-MRI is a reliable screening and diagnosing method for characterization of pancreatic lesions.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
305
314
https://svuijm.journals.ekb.eg/article_216309_f246ee5ab26124bbc932ba035cd5595f.pdf
dx.doi.org/10.21608/svuijm.2022.116250.1265
Effect Of Sodium Fluoride On The Liver Of Male Albino Rats And The Possible Protective Role Of Vitamin C
Mohamed Nader
Abd El–Razik
Department of Human Anatomy and Embryology, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Ahmed Talat
Galal
Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Salwa Mohamed
Ouies
Department of Human Anatomy and Embryology, Faculty of Medicine, Sohag University, Sohag, Egypt
author
text
article
2022
eng
Background: The liver alters exogenous and endogenous chemicals, foreign molecules and hormones to make them less toxic or less biologically active. The Fluoride causes impairment of liver function, causing decrease in metabolic activities, increased serum indices of liver function tests and inhibits certain antioxidant enzymes and molecules. Objectives: To evaluate the effect of Sodium Fluoride (NaF) on the liver of male albino rats and the role of Vitamin C. Animals and methods: This study was carried out on 30 adult male albino rats. The rats were randomly categorized into 3 equal groups of animals, 10 animals for each. Animals were given normal saline in Group (A), sodium Fluoride in Group (B),sodium Fluoride and Vitamin C in Group (C). Results: Sodium Fluoride caused toxic effects on the liver. In the form of loss of normal pattern, dilated congested thick walled portal vein that contained hemolysed blood cells. Also there was mild dilatation in the thick walled hepatic artery and in the bile duct. After treatment with Vitamin C, there was an improvement in the picture of the liver. Conclusion: Vitamin C can diminish these toxic changes induced by NaF on the liver tissue.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
315
324
https://svuijm.journals.ekb.eg/article_216896_72c46d74ec82aea47791be7414c56e9d.pdf
dx.doi.org/10.21608/svuijm.2022.110511.1251
Evaluation of using agar combined with phototherapy in management of neonatal unconjugated hyperbilirubinemia
Ahmed El-Abd
Ahmed
Pediatrics Department, Faculty of Medicine South Valley University, Qena, Egypt
author
Marcos Victor
Nazeer
Pediatrics Department, Faculty of Medicine South Valley University, Qena, Egypt
author
Ali Helmi
Bakri
Pediatrics Department, Faculty of Medicine South Valley University, Qena, Egypt
author
text
article
2022
eng
Background:Neonatal hyperbilirubinemia is a common problem in neonates.Phototherapy is an efficient way to decrease the accumulation of bilirubin, although it involves hospitalization, and can force the baby to stop eating due to the breast separation. In certain cases of infant jaundice, the hepatic circulation of bilirubin plays a major role Objectives: The purpose of the study was todetermine the value of oral agar ingestion combined with phototherapy in management of neonatal unconjugated hyperbilirubinemia and to compare it with the use of phototherapy alone in the management. Patients and methods: This was a randomized controlled study conducted at Neonatal intensive care units in Qena university hospital and Qena general hospital. They were divided into: Case group (neonates received oral agar with phototherapy).Control group (neonates received phototherapy alone). The duration of this study was 6 months. Results: The study included 517 neonates,314 neonates (60.74%) treated withphototherapy alone and 203 neonates (39.26%) treated withphototherapy combined with agar .There was a significant decrease in total serum bilirubin (TSB) in both subgroups, but the decrease was more significant in term male babies andin group that received agar with phototherapy than the group received phototherapy alone. Conclusion: Our results show that the administration of oral agar in full-term neonates was safe to decrease total serum bilirubin (TSB) concentrations and to shorten the length of phototherapy in hyperbilirubinemic neonates. As a supplementary treatment for neonates with hyperbilirubinemia, our results indicated that agar may benefit in minimizing the length of hospitalization.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
325
330
https://svuijm.journals.ekb.eg/article_135189_993284711eb2d25e4fa5baa5e9ce912f.pdf
dx.doi.org/10.21608/svuijm.2021.50638.1047
Comparative Study between Protective Effects of L-Carnitine and Curcumin on Nephrotoxicity Induced by Cisplatin in Adult Male Albino Rats
Noha Aboelnaga
Ashour
Human Anatomy and Embryology Department, Faculty of Medicine, South Valley University ,Qena, Egypt
author
Dorreia Abd Allah
Mohamed
Human Anatomy and Embryology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Maha Abd Elbaki
Ahmed
Human Anatomy and Embryology Department, Faculty of Medicine, South Valley University ,Qena, Egypt
author
text
article
2022
eng
Background: Cisplatin is regarded as a main anticancer drug. However, nephrotoxicity is its major side effect and chief dose-limiting factor. L-carnitine (LC) is a natural nutrient, while Curcumin (CMN) is derived from turmeric (Curcuma longa) plants. Both could prevent nephrotoxicity.
Objectives: To evaluate nephrotoxicity induced by cisplatin ,detect protective effect of L-carnitine and curcumin in reducing cisplastin nephrotoxicity and determine which is more potent .
Materials and Methods: Forty adult male albino rats were randomly divided into 4 groups ten rats each; Group1; Control group, received isotonic saline, 2. Group 2; cisplatin treated (7mg/kg body weight as a single dose), Group 3; treated with LC (500 mg/kg/day) plus cisplatin, Group 4; treated with cisplatin plus CMN (100mg/kg /day).The duration of experiment was 10 days. Specimens were prepared for light and electron microscopic examination. Morphometric and statistical studies were done to measure the diameter of proximal convoluted tubules (PCT) and Bowman's space.
Results: The cisplatin-treated rats had destructive damage of the renal glomeruli including all types of pathological changes in the cortex and marked degeneration of the proximal convoluted tubules (PCTs). The treatment with LC and curcumin prevented severe damage caused by cisplatin. However LC treated rats showed more improvement than CMN treated group.
Conclusions: Administration of L-carnitine with cisplatin decreases its nephrotoxicity which is the major cisplatin side effect.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
331
342
https://svuijm.journals.ekb.eg/article_217126_dc7b23c1807986dbd656c797b1516f14.pdf
dx.doi.org/10.21608/svuijm.2022.115758.1264
Cardiovascular Risk Factors and Metabolic Syndrome in Patients with Knee Osteoarthritis
Mai Mahmoud Mohammed
Hassan
Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mohamed Ismail
Abdelkreem
Rheumatology and Rehabilitation Department, Faculty of Medicine, AL-Azhar University (Assiut Branch),Egypt.
author
Hossam Eldin M.
Mahmoud
Internal Medicine Department, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Amr Mohammed
Mohammed
Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2022
eng
Background: Osteoarthritis (OA) is the commonest musculoskeletal disease; the relation between knee osteoarthritis, cardiovascular risk factors and metabolic syndrome (Mets) has been previously reported but not yet thoroughly studied.
Objectives: to evaluate the relation between cardiovascular risk factors and metabolic syndrome and knee osteoarthritis.
Patients and methods: This is a hospital-based cross-sectional study, was done on 200 patients with knee OA at outpatient clinic of physical medicine, Rheumatology, and Rehabilitation Department of Qena University Hospital.
Results: 200 patients in this study with mean age (56.7 ±10.3) P value (0.001) , mean body mass index (BMI)(27.5±4.5) P value (0.313)and mean disease duration (10±5.5) P value (0.003). 111 of patients who have abnormal ECHO ((49.1%) of them were diabetic, (85.7%) hypertensive, (58.9%) obese, (58%) hyperlipidemic, (84.8%) of them have full criteria of metabolic syndrome. 119(59.5%) of knee osteoarthritis patients that involved in this study have metabolic syndrome.
Conclusion: The findings of this study showed that there is an association between cardiovascular risk factor, metabolic syndrome and knee osteoarthritis and show their significant role in the development and progression of knee osteoarthritis.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
343
349
https://svuijm.journals.ekb.eg/article_218870_6c110a64fb669dffb208fc6a99da8d91.pdf
dx.doi.org/10.21608/svuijm.2022.118452.1269
The effects of Aspartame on the postnatal development of the cerebellum in male albino rat offspring
Omyma Zeanelabdeen
Fakhry
Human Anatomy and Embryology Department, Faculty of Medicine, South Valley University,Qena, Egypt.
author
Dorreia AbdAllah
Mohamed
Human Anatomy and Embryology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
author
Maha Abdelbaki
Ahmed
Human Anatomy and Embryology Department, Faculty of Medicine, South Valley University,Qena, Egypt.
author
text
article
2022
eng
Background: Aspartame (ASP) is a non-nutritive sweetener that is greatly used in drinks, foods, beverages and pharmaceuticals. There are controversies about its safety. So, studies are important to prove or disapprove the present fears about aspartame.
Objectives: It is to evaluate the effect of ASP on the postnatal development of cerebellum in rat offspring.
Material and Methods: Eight male offspring of each control and experimental groups were randomly selected at the postnatal day (PND): 1,7,15.21 and 60 days. Aspartame (250 mg/kg body weight/day) was given orally to experimental group of animals during pregnancy and lactation period. Specimens were prepared for light and electron microscopic studies. Morphometric and statistical studies were done to measure the diameter of granular cells nuclei.
Results: Control group of animals showed normal development of cerebellar cortex. Cerebella of the experimental group of animals showed a disrupted architecture with degenerative changes especially in Purkinje cells. Splitting and disruption of the myelin sheath were detected. Experimental group showed a highly significant decrease in the mean granular cell nuclear diameter (p < 0.001) when compared to the control group.
Conclusions: Administration of aspartame during pregnancy has harmful effects on the developing cerebellum of albino rat’s offspring.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
5
v.
1
no.
2022
350
364
https://svuijm.journals.ekb.eg/article_175181_23d65baf314a809542f8a1df8bf90972.pdf
dx.doi.org/10.21608/svuijm.2021.72153.1164