Issue Information
Ali A.
Ghweil
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Ahmed H.
Abdellah
Department of Obstetrics and Gynecology, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Mohammed H.
Hassan
Department of Medical Biochemistry and Molecular Biology, Qena Faculty of Medicine, South Valley Uni
author
text
article
2021
eng
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
0
0
https://svuijm.journals.ekb.eg/article_198366_cf3cf063288b155301aa6f9bab4ee47c.pdf
dx.doi.org/10.21608/svuijm.2021.198366
Relationship between Red Blood cell Distribution Width and Extent of Coronary Artery Disease in Patient with ST Elevation Myocardial Infarction
Mai Ahmed
Hamza
Department of cardiology, Faculty of Medicine, Al-Azhar university (Assiut branch), Egypt
author
Mohammed
Mahmoud
Department of cardiology, Faculty of Medicine, Al-Azhar university (Assiut branch), Egypt
author
Mahmoud
Abd-el Ghaffar
Department of cardiology, Faculty of Medicine, Al-Azhar university (Assiut branch), Egypt
author
Ahmed
El-Tayeb
Department of cardiology, Faculty of Medicine, Al-Azhar university (Assiut branch), Egypt
author
text
article
2021
eng
Background: Coronary Artery Disease (CAD) is the leading cause of morbidity and mortality all around the world. Red cell distribution width (RDW) is an indicator for the variability and size of circulating erythrocytes, has recently been shown to be an independent predictor of prognosis in patients with cardiovascular disease. Objectives:to assess the relationship between RDW and severity of coronary artery disease (CAD) by SYNTAX score in patients with ST-elevation myocardial infarction (STEMI) undergoing coronary angiography. Methods:Eighty consecutive patientswho underwent coronary angiography after diagnosis of STEMI, were enrolled in this study which was conducted at cardiology department of Qena university hospital and Qena general hospital at period from October 2018 to July 2019. Results: there was no statistical significant difference (p-value > 0.05) between normal RDW patients and Abnormal RDW patients as regard demographic data(age, sex, BMI, smoking, HTN, dyslipidemia) except for DM, there was statistical significant difference, also there was no statistical significant difference (p-value > 0.05) between normal RDW patients and Abnormal RDW patients as regard laboratory data (eGFR,WBCs, neutrophils, lymphocytes,N/L ratio). While there was statistically significant difference (p-value < 0.05) between normal RDW patients and Abnormal RDW patients as regard LVEF, SWMA, number of affected vessels and SYNTAX score. After adjusting for all correlates, patients was high syntax scores were 3.6 times more liable for having abnormal RDW class (AOR=3.6, 95% CI: 1.2–7.3, p-value =0.029). Conclusion:Red cell distribution width is positively correlated with number of diseased vessels and high syntax score and extent of coronary artery disease.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
1
13
https://svuijm.journals.ekb.eg/article_158421_3739d3720d2f037cfda2a01da5f60ee1.pdf
dx.doi.org/10.21608/svuijm.2021.64583.1100
Assessment of Fecal Calprotectin level in Inflammatory, Infectious and Malignant Gastrointestinal Diseases
Hasan Sedeek
Mahmoud
Associate Professor , Tropical Medicine and Gastroenterology Department, Faculty of Medcine, South Valley University, Qena, Egypt
author
Hanan Mahmoud
Fayed
Professor, Chemical and Clinical Pathology, Faculty of Medicine, South Valley University,Qena, Egypt
author
Mahmoud
El Dosoky
Teaching Assistant , Pathology Department,Faculty of Medicine, South Valley University, Qena, Egypt
author
Mohammed
Tag-Adeen
Associate professor , Internal Medicine Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Background: Calprotectin is a marker of inflammation as it is a cytosolic protein in the neutrophilic granulocytes. Objectives: We aimedto assess fecal calprotectin (FC) in the inflammatory, infectious and malignant gastrointestinal (G.I.T) diseases. Patients and Methods: 169 patients presented with G.I.T symptoms and proved with inflammatory, infectious or malignant condition by histopathological examination of the G.I.T endoscopic specimens were recruited. Symptomatic subjects with normal findings were considered as a non-organic; comparable group. Complete blood count, E.S.R, C.R.P, liver function tests, kidney function tests and stool analysis followed by endoscopic examination and multiple biopsies were taken for histopathological examination. FC was measured for all subjects. Results: Out of 169 patients; 79 patients (53.7%) showed inflammatory/infectious lesions (34 of them were inflammatory bowel disease (I.B.D)), 68 (46.3%) were malignant lesions and, 22 of them showed non-organic lesions (13%). FC levels (median, IQR; interquartile range) were significantly higher in inflammatory, infection group and malignant group than in the non-organic group (145 (53-2467) and 136 (45-212) versus 17 (10-57) respectively, P value =0.000). Patients with I.B.D showed significantly higher values for FC than in those with non I.B.D, P value= 0.000. Colorectal cancer patients showed higher FC values than gastric or esophageal cancer, P value= 0.000. Conclusions: FC is a useful marker in the diagnosis of G.I.T inflammatory, infectious and malignant conditions especially in I.B.D and colorectal cancer.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
14
24
https://svuijm.journals.ekb.eg/article_129054_b0c3aeed450c10f588927e74dbe23c81.pdf
dx.doi.org/10.21608/svuijm.2020.49745.1044
Neurological Diseases: Cause and Effect in the Era of COVID-19
Islam
Elmalky
Department of Neurology, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Eptehal
Dongol
Department of Chest Disease, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Hazem
Abdelkhalek
Department of Neuropsychiatry, Faculty of Medicine, Tanta University, Tanta, Egypt.
author
text
article
2021
eng
Background: SARS-CoV-2 new infectious disease was first reported in Wuhan, China in December 2019. Thereafter, it has extensively spread causing global pandemic. It was named as corona virus disease 2019 (COVID-19) by WHO in February 2020. Other than the well described COVID-19 respiratory and cardiac manifestations, the neurological manifestations are not that uncommon. Objectives: In this review, we are trying to shed light on this pandemic disease and its neurological presentation, which might enable neurologists to pick up and promptly deal with such cases. The COVID-19 neurological presentation can include many diverse symptoms and rapid clinical deterioration can be related to development of neurological affection. Moreover, the patients with already neurological diseases, when affected by the COVID-19 showed worse prognosis. Conclusion: Enhanced research is needed to illustrate and explain and hence development and tailoring adjusted treatment for the neurological manifestation for better management of such cases to improve the outcome.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
25
37
https://svuijm.journals.ekb.eg/article_152661_d9d2f75632ad46e9002a4dfb968639c0.pdf
dx.doi.org/10.21608/svuijm.2021.63964.1094
Flap Selection Approach for Hand Soft Tissue Defects Reconstruction: Surgical Techniques and Outcome Evaluation
Ghada S.
Gad
Plastic Surgery Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Samia M.
Saied
Plastic Surgery Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Mohamed Abdelshafy
Mohamed
General Surgery Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Mahmoud A.
Hifny
Plastic Surgery Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Background: The hand is an intricate part of the body that plays an essential role in social functioning, expression, productivity, and interactions with our environment.Many flap options have been described to address the specific functional and anatomic requirements in soft tissue reconstruction of the hand. The aim of this study isto find the ideal donor tissue for coverage of soft tissue defects of the hand to achieve wound closure and maintain joint and hand function. Patients and methods: A prospective study wasconducted betweenfrom April 2018 and May 2019, on all patients with soft tissue defects of the hand presented to plastic surgery department, Qena faculty of medicine,South Valley University. Results:There were 62 hand injuries in 50 patients with a mean age of 35 years (range, 1- 69 years). The etiologies of the injuries were mostly due to post-traumatic raw areas (86%). In our study we divided cases into 4 main groups, the first group including fingertip injuries, second group proximal to fingertips, third group palm and fourth group dorsum of the hand. The distribution of the hand injuries were 48 fingertips injury, 8 injuries proximal to fingertips, palm injury in one patient and injuries over hand dorsum in 5 patients.The follow up period was ranged 1 to 6 months. Conclusion:An algorithmic approach for coverage of the hand soft tissue defect seems to provide predictable results regarding flaps survival and preservation of finger length.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
38
44
https://svuijm.journals.ekb.eg/article_134892_1af122a3a364ffd364bc3c5b03b72070.pdf
dx.doi.org/10.21608/svuijm.2021.49987.1045
Thoracic Tuberculous Spondylitis: Posterior Approach Single-Stage Stabilization, Debridement, and Local Grafting
Hamdy
Tammam
Department of Orthopaedic Surgery, Faculty of Medicine, South Valley University, Qena, Egypt
author
Elsayed
Said
Department of Orthopaedic Surgery, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Background: Different approaches are employed to treat patients with Pott’s disease who are candidates for surgical intervention. Each of these approaches has advantages and disadvantages. Objectives: This retrospective study presents the surgical, clinical, and radiological outcomes of posterior alone single-stage debridement and grafting of single-level tuberculous discitis using local graft from the decompression and nearby spinous processes. Patients and Methods: Between 2012 to June 2016, 15 patients with thoracic tuberculous spondylitis were operated up through posterior approach starting with one side fixation thorough debridement of the lesion and the use of local graft form decompression and spinous process bone. Clinical evaluation was done using Visual Analogue Scale (VAS) for back pain, Oswestry Disability Index (ODI), and Frankel Grade classification. Radiological assessment of kyphotic angle and fusion was also performed. Results: The mean operative time was 115.3 ± 23.6 minutes. The mean amount of blood loss was 571.3 ± 142.4 ml. Hospital stay ranged from 3 to 7 days (mean 4 ± 0.6 days). Patients were followed for 30.27 ± 6.5 months. All patients showed significant improvement in clinical and radiological parameters. Twelve patients showed neurological improvement. One patient required reoperation for neurological deterioration. Radiological follow-up showed solid fusion within 6 months postoperatively. Conclusion: Single-stage debridement of thoracic Pott’s lesion with the use of transpedicular fixation and local graft under perioperative coverage of antitubercular chemotherapy yielded satisfactory results avoiding the need for the more morbid and technically demanding anterior procedures and the graft donor site morbidity.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
45
68
https://svuijm.journals.ekb.eg/article_169101_a84a99f2a0b58f38b7bc014afd568ff5.pdf
dx.doi.org/10.21608/svuijm.2021.74809.1175
Relation between serum levels of Vitamin D and Immunoglobulin E in Allergic Rhinitis in Upper Egypt
Aida A.
Abdelmaksoud
ENT Department, Faculty Of Medicine, South Valley University,Qena, Egypt.
author
Shamardan ES
Bazeed
Tropical Medicine and Gastroenterology Department, Faculty Of Medicine, South Valley University,Qena, Egypt.
author
Mohamed F
Alemam
Clinical and Chemical pathology Department, Faculty Of Medicine, South Valley University,Qena, Egypt.
author
Zaky
Aref
ENT Department, Faculty Of Medicine, South Valley University,Qena, Egypt.
author
text
article
2021
eng
Objective: The object of this study is to evaluate the relation between 25- hydroxy cholecalciferol (vitamin D3) deficiency and allergic rhinitis by detecting level of 25-hydroxy cholecalciferol and Immunoglobulin E serum levels. Methods: This is a case-control study in which we compare two groups; group A included 69 patients diagnosed as allergic rhinitis (AR) and group B included 60 healthy individuals. Serum levels of cholecalciferol and serum levels of immunoglobulin (IgE) were assessed in all participants of both groups of this study. Results: Serum level of 25- hydroxy cholecalciferol in group A (AR patients) was statistically significantly lower (mean ± SD: 14.2±8.04 ng/ml) than serum level of 25-hydroxy cholecalciferol in group B (21.1±8.2ng/ml). Also serum level of IGE in group A was markedly elevated in comparison to group B (494.4±61.7u/l) vs. (189.9±52.9u/l) with highly statistically significant difference (p-value < 0.001). Conclusion: There is statistically significant relation between 25-hydroxy cholecalciferol deficiency and allergic rhinitis; further studies must be done to assess the effect of Vitamin D3 therapy in allergic rhinitis.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
69
75
https://svuijm.journals.ekb.eg/article_119472_fe7dbd8c7dca45586d0fe0ab52694984.pdf
dx.doi.org/10.21608/svuijm.2020.45265.1014
Acute kidney injury in neonatal sepsis: prevalence, and outcome
Magda Farghali
Gabri
Pediatrics Department, Faculty Of Medicine, Aswan University, Aswan, Egypt.
author
Waleed Ahmed Ibrahim
Eltabakh
Pediatrics Department, Faculty Of Medicine, Aswan University, Aswan, Egypt.
author
Asmaa Osama
Osman
Clinical Pathology Department, Faculty Of Medicine, Aswan University, Aswan, Egypt.
author
Hanan Mohammed
Aly
Pediatrics Department, Faculty Of Medicine, Aswan University, Aswan, Egypt.
author
Edrees Hasan
Zaki
Pediatrics Department, Faculty Of Medicine, Assiut University, Assiut, Egypt.
author
text
article
2021
eng
Background: Acute kidney injury (AKI) is an acute and reversible increment in serum creatinine levels regardless of associated or not with a decrease in urine output. AKI is very common among septic neonates. The high mortality among septic neonates with AKI stresses the need for screening them for renal failure. Early recognition of risk factors for AKI may reduce the risk of its occurrence. Objective:This study aimed to evaluate AKI's prevalence and outcome in neonates with neonatal sepsis in our hospital. Patients and methods: This study was an observational cross-section study carried out on all neonates ≥ 28 weeks admitted to our hospital in 6 months duration. History, examinations, and urine output were assessed and followed up regularly. Laboratory investigations included CBC, CRP, ESR, urine analysis, Urea and Creatinine, and Blood culture. Results: AKI presented in 67.2% of septic neonates based on oliguria while raised serum creatinine, shown in 4.5% of cases. Mean urine output was (1.26 ± 0.6) ml/kg/hr, 60 % of patients with AKI were males, 38% were preterm, 47% were LBW, and mortality was 51.1%. Conclusion: more than two-third of neonates with sepsis had AKI. Gestational age and weight were less in cases with AKI, with more than half of them were full-term and ≥ 2.5 kg. Gender was not a significant risk factor for AKI in sepsis. Mortality was significantly higher in AKI, mainly in full-term and low birth weight. Dead neonates with AKI were less anemic, less leucopenic, and more thrombocytopenic than living.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
76
89
https://svuijm.journals.ekb.eg/article_130547_40bd92d5d9236286e6f0e953752b570d.pdf
dx.doi.org/10.21608/svuijm.2020.49064.1036
Role of diffusion weighted imaging in diagnosis of cholesteatoma: A single centre study
Aida A.
Abdelmaksoud
ENT Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Saeda
Abd Elwahab
Radiodiagnosis Department, Faculty of medicine, South Valley University, Qena, Egypt
author
Usama
Tayee
ENT Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Back ground: Diffusion weighted imaging was introduced to improve the detection of middle ear cholesteatomas. By computed tomography, difficulty was found as cholesteatoma shows middle ear opacity similar to chronic otitis media in cases with no bone erosion, Objectives: Purpose of this study to clarify the role of diffusion-weighted imaging in the diagnosis of cholesteatoma and differentiating it from chronic otitis media. Methods: Cross sectional study of 20 patients, All patient treated medically, followed, surgery was done in those not responding to medical treatment after one month. T2WI and DWI and ADC map were done, results assessed by SPSS system version 20 and Chi square test. Sensitivity, specificity, positive and negative predictive vales assessed. Results: 20 patients (9 males and 11 females), ages 15-35 and mean age = ± 25 year, 10 of them showed middle ear hyperintense signal intensity lesion in T2 weighted image, restricted diffusion, and low apparent diffusion coefficient values, mean value was about = ± 0.75 ± 0.26 x10-3 mm2/s,11 patients were confirmed cholesteatoma. 10 patients showed hyperintense signal intensity lesion in T2WI, facilitated diffusion and high apparent diffusion coefficient values, mean value = ± 1.75 ± 0.14 x10-3 mm2/s, 9 confirmed otitis media by complete resolution after antibiotic treatment and follow up. Sensitivity of diffusion-weighted imagining 90.0%, specificity 88.9%, positive and negative predictive value 90.9% and 88.9%. Conclusion: Diffusion-weighted imagining has a high sensitivity and diagnostic accuracy in differentiation of cholesteatoma from otitis media in overlapping cases.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
90
98
https://svuijm.journals.ekb.eg/article_123246_7be18fdf5edde4f6e11e81336260693a.pdf
dx.doi.org/10.21608/svuijm.2020.48451.1031
A New Regimen for Induction of Metabolic Syndrome and the Effect of Febuxostat in Ovariectomized Female Albino Rats
Rana
Toghan
Department of Medical Physiology, Qena faculty of medicine, South Valley University, Qena 83523, Egypt
author
Rehab H.
Abdel-Aziz
Department of Medical Physiology, Qena faculty of medicine, South Valley University, Qena 83523, Egypt
author
Tahany
Abbas
Department of Medical Histology, Qena faculty of medicine, South Valley University, Qena 83523, Egypt
author
Khaled A.
Abdel-Sater
Department of Medical Physiology, Faculty of Medicine, Al-Azhar University (Assuit Branch), Assuit 71524, Egypt
author
text
article
2021
eng
Background: Metabolic syndrome (MetS) is increasing worldwide and correlates with serum uric acid and high fat combined with highfructose diet (HFFD). Fat raises triglycerides. Fructose increases uric acid. We hypothesized that HFFD in menopause may have a pathogenic role in MetS and using febuxostat may improve it by attenuating oxidative stress and vascular inflammation. Objectives: This study aimed to assess effects of ovariectomy and HFFD diet on causing MetS for rats and effects of febuxostat on MetS of ovariectomized rats. Materials and methods: The study was carried on 50 female white albino rats, aged 3 months and weighted 170 to 300 gm. 50 rats were divided into: sham control, ovariectomized control,HFFD non-ovariectomized, HFFD ovariectomized and febuxostat HFFD ovariectomized group. HFFD was composed of 45% fat and 30% fructose for 12 weeks. The latter group received febuxostat for 8 weeks. Results: HFFD was associated with significant increased adiposity index (5.92±0.41), serum triglycerides (109.7±32.39 mg/dl), HOMA-IR (4.03±1.62) and serum uric acid (5.99 ±0.528 mg/dl). Ovariectomy has a synergistic effect with HFFD. HFFD with ovariectomy was also associated with significant increasedadiposity index (11.49±1.5),serum triglycerides (223.2±67.6 mg/dl), HOMA-IR (11.48±2.01) and serum uric acid (7.64±1.615mg/dl). Febuxostat was able to reverse these effects significantly in adiposity index (7.94±0.489), serum triglycerides (121.7±17.6 mg/dl) and serum uric acid (1.96±0.64mg/dl) but insignificant effect on HOMA-IR. Conclusions : Fructose and fat in menopause may have a major role in incidence of MetS. Febuxostat prevent pathological condition ofMetSby different mechanisms of action
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
99
107
https://svuijm.journals.ekb.eg/article_121551_044ac6c8b5a3abef5cfae27cfd11d42d.pdf
dx.doi.org/10.21608/svuijm.2020.45556.1015
Age-related Histological Changes in the Renal Telocytes in Male Albino Rats
Abeer Madkour
Mahmoud
Human Anatomy & Embryology Department, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Dorreia Abdallah Mohamed
Zaghloul
Human Anatomy and Embryology Department, Faculty of Medicine, Assuit University, Assiut, Egyptز
author
Fatma Y.
Meligy
Histology and Cell Biology Department, Faculty of Medicine, Assuit University, Assiut, Egypt
author
Maha AA
Fahmy
Human Anatomy & Embryology Department, Faculty of Medicine, South Valley University, Qena, Egypt.
author
text
article
2021
eng
Background:Many researches on telocytes (TCs) have proved its existence, structure and specific immune markers expression in many normal organs and in different species. Multiple physiologic functions have been suggested for these cells. Objectives: This study is designed to evaluate age-related changes ofTCs in different age groups in the renal tissue. Materials and Methods: 18 male Sprague- Dawley rats were used in this study and divided equally into 3 groups (each consists of 6 rats); Group I (rats aged 3 weeks), Group II (rats aged 3 months, adult) and Group III (rats aged one year). All rats of group I, II and III were sacrificed and each group was divided into two subgroups. The first subgroup was processed for light microscopic and immunohistochemical staining. The second subgroup was processed for electron microscopy. Morphometric and statistical studies were conducted. Results: TCs with their characteristic long and thin cytoplasmic projections (telopodes, Tps) are detected in each of H&E stained and CD34 immunostained sections. In group III, there is a significant reduction of the TCs count. TEM examination of the ultrathin sections revealed shrinkage of TCs with disintegration and fragmentation of the Tps with a significant reduction of the number of Tps arising from each TC in group III. In all groups of the study, homocellular and heterocellular junctions are observed. Conclusion: On comparison of the age groups in the study, it is proved that TCs decrease in number with degenerative changes observed with aging.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
108
119
https://svuijm.journals.ekb.eg/article_184636_e778111e7a893acc59f75b72b50c48dc.pdf
dx.doi.org/10.21608/svuijm.2021.84197.1190
Effect of Tramadol Abuse on Male Fertility
Aya
Saadeldin
Department of Medical Pharmacology, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Al Shaimaa
Hasan
Department of Medical Pharmacology, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Mohammed
Hassan
Department of Medical Biochemistry , Faculty of Medicine, South Valley University, Qena, Egypt
author
Gamal A.
Alsagheer
Department of Urology, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Background: addiction is still an increasingly social and health issue worldwide, despite all attempts to overcome it. Analgesics are of the most prevalent substances that are abused. In Egypt and the Middle East, tramadol abuse is highly increasing. This can be correlated to its inexpensive cost, large availability, accessibility and illegal trafficking. Tramadol is a centrally-acting synthetic opioid analgesic that is commonly used to treat different intensities of pain varying from mild to extreme pain conditions. Prolonged administration of tramadol can result in abnormalities of the hypothalamic-pituitary function and decrease in testosterone production. Many experimental studies were done and showed that tramadol affects the level of luteinizing hormone, follicular stimulating hormone, testosterone, estradiol, and prolactin. It also affects sperm quality and motility. We aimed in this review: is to delineate these issues. Conclusion: There is a significant correlation between tramadol abuse and impaired gonadal and male sex hormone and sperm quality parameters.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
120
127
https://svuijm.journals.ekb.eg/article_117987_94a6b380f6e0eb773f0728b3969ae91f.pdf
dx.doi.org/10.21608/svuijm.2020.45252.1013
Prognostic value of CD10, BCL6 and MUM1 in diffuse large B-cell lymphoma
Asmaa M.
Ahmed
Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Sally S.
Abdel-Hakeem
Department of Oncologic Pathology, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut , Egypt
author
Maged AF
Amine
Medical Oncology Department, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut, Egypt.
author
Etemad H.
Yassin
Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Fatma A.M.
Badary
Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
author
text
article
2021
eng
Background: Diffuse large B-cell lymphoma (DLBCL) is considered the commonest subtype of non-Hodgkin lymphoma (NHL) in the world. It is a refractory disease with a high mortality rate due to frequent relapses. Several prognostic parameters are now widely studied for risk stratification and achieving a better outcome. Objectives: In this study, we aim to assess the prognostic value of immunohistochemical expression of CD10, BCL6, and MUM1 independently as surrogate markers for cell of origin (COO) classification of DLBCL and their correlation with clinicopathological characters and survival. Patients and methods: This is a retrospective study conducted on 63 cases of DLBCL, NOS. Full-faced sections were constructed and immunostained for CD10, BCL6, and MUM1. Results: CD10 expression was associated with early-stage (P=0.003), normal serum LDH level (P=0.022), absence of B symptoms (P=0.019), low international prognostic index (IPI) and age-adjusted-IPI (P=0.001) and also associated with longer progression free survival (PFS) (P=0.006). BCL6 expression was associated with centroblastic variant (P=0.005), good ECOG performance status (P=0.038) and low IPI (P=0.004) and also associated with better overall survival (OS) (P=0.028) and PFS (P=0.018). MUM1 expression was associated with advanced-stage (P=0.002) while no significant association was detected with other clinicopathological parameters or survival. Conclusion CD10, BCL6, and MUM1 can be used independently as prognostic immunohistochemical markers for DLBCL that may denote the clinical behavior of the disease and further patients' outcomes.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
128
140
https://svuijm.journals.ekb.eg/article_182977_f445696eb258a69de0da72ebad6539ab.pdf
dx.doi.org/10.21608/svuijm.2021.82242.1185
Hepatocellular Regeneration and Necrosis Markers in Chronic HCV Patients under Sofosbuvir-Based Regimen
Amr
Alnoby
Chemical and Clinical pathology Department,
Faculty of Medicine,
South Valley University, Qena, Egypt
author
Abdallah Elaiw Mohamed
Ali
Chemical and Clinical pathology Department,
Faculty of Medicine,
South Valley University, Qena, Egypt
author
Ayman S.
yassin
Microbiology and Immunology Department, Faculty of Medicine, Al-Azhar University, Assiut branch, Assiut, Egypt
author
Hanan Mahmoud
Fayed
Chemical and Clinical pathology Department,
Faculty of Medicine,
South Valley University, Qena, Egypt
author
Hasan Sedeek
Mahmoud
Tropical Medicine and Gastroenterology Department, Faculty of medicine, South Valley University, Qena, Egypt.
author
text
article
2021
eng
Objectives: To evaluate noninvasive fibrosis markers, retinol binding protein 4 (RBP4), and alpha-feto protein (AFP) in foreseeing liver fibrosis in persistent hepatitis C patients and their correlations with Fibroscan. Materials and Method: Fifty naive CHC patients and 20 healthy age and sex-matched subjects as controls were included. Blood samples and fibroscan obtained before and 3 months after treatment with DAAs for CBC, INR, and Liver function tests, RBP4, AFP and different fibrosis markers as APRI, CDS, FIB-4, GUCI, Lok index. Results: All patients achieved SVR (12 weeks) with an change of liver function and decrease of liver fibrosis as measured by Fibroscan. The Fib-4 score gave the best performance and diagnostic accuracy for the prediction of the presence of significant fibrosis, then (APRI and GUCI) followed by the CDC and LOK index; and lastly RBP4 as they were efficient to differentiate significant fibrosis (moderate and severe) liver scarring (F2-F3) from mild fibrosis (F0-F1). However; the accuracy of RBP4 improved with a higher fibrosis grade and thus can differentiate the presence or absence of severe (F3-F4) from mild & moderate (F1-F2) liver scarring with 93.75% for PPV and NPV but with a poor prediction of the absence of significant fibrosis (F1 versus F2–F3), while LOK score was excellent in the prediction of the absence of significant fibrosis (F1 versus F2–F3). Conclusions: FIB-4, APRI, GUCI, CDS, and Lok index were accurate to predict the fibrosis grade in CHC patients, correlated with hepatic injury and can assess DAAs treatment success.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
141
149
https://svuijm.journals.ekb.eg/article_129074_aa62e45017a299e27636317aa57e144d.pdf
dx.doi.org/10.21608/svuijm.2020.47893.1023
Endometrial Hyperplasia: Different Classification systems and Advantages of WHO 2014 Classification System.
Maisa
Mohammed
Pathology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Nagwa
Ahmed
Pathology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
text
article
2021
eng
Background: Endometrial hyperplasia (EH) is a pathological condition which occurs due to unopposed estrogenic effect. It is usually manifest by abnormal uterine bleeding affecting women in 5th and 6th decades of life. Some cases of endometrial hyperplasia especially those with atypical cytological features may progress to endometrial adenocarcinoma, while others follow an indolent course. Several classification systems have been developed over years. Early classifications were based on structural and cytological features. However, the recently developed classification system by WHO in 2014 was based mainly on the cytological atypical features as the architectural features have been proved to be clinically irrelevant. Cellular morphology was also included in this classification system. Conclusions: WHO 2014 classification system described both cellular morphology and nuclear atypia as some newly described variants like atypical mucinous glandular proliferation was proved to be precancerous despite of its minimal cytological atypia. Glandular architectural features were proved to be clinically irrelevant, so they were excluded from this classification.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
150
154
https://svuijm.journals.ekb.eg/article_120431_0762f3b9a54e634fa209da22eb8bb716.pdf
dx.doi.org/10.21608/svuijm.2020.45949.1016
The impact of involved node radiotherapy on organs at risk on treatment of limited stage Hodgkin lymphoma
Mostafa E.
Abdel-Wanis
Department of Radiation oncology and Nuclear Medicine, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
author
Mona M.
Sayed
Department of Radiation oncology and Nuclear Medicine, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
author
Asmaa E.
Hasaballah
Department of Radiation oncology and Nuclear Medicine, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
author
Amany G.
Ali
Department of Radiation oncology and Nuclear Medicine, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
author
text
article
2021
eng
Background: Radiotherapy isan important component of the combined modality treatment of limited stage Hodgkin lymphoma. Using such combination resulted in high cure ratesexceeding 90%. Unfortunately, long-term survivors are at increased risk of critical long-term morbidities including second malignancy,lung, and cardiac toxicities. Radiation induced toxicity is related to dose and field size. The concept of involved node radiotherapy (INRT) is to minimize the irradiated volume to cover only the primarily involved nodes, while maintaining high local control rates. Objectives:The aim of this study is to analyze to what extent reducing the target volume using INRT compared with involved field radiotherapy IFRT, can minimize doses to adjacent normal tissues. Patients and methods: 20 patients diagnosed with limited stage HL who received 2-4 cycles of ABVD were planned to receive consolidation radiotherapy. For each patient, two plans were generated: IFRT and INRT. The radiotherapy dose used was 20-30 Gy. Organs at risk OARs including lungs, heart, breasts, and thyroid gland were delineated and different dosimetric parameters of both plans were compared. Results: compared to IFRT, INRT showed significant reduction in mean doses and dose-volume metrics ofcontoured OARs.Mean dose to the heart (17.47/8.98 Gy), to lung (11.5/7.3 Gy), to breasts (left 3.1/1.8 Gy, and right 3.3/1.6 Gy) and to thyroid (17.5/7.1Gy). Conclusion: reducing the treatment volume from IFRT to INRT is associated with decrease in radiation exposure of OARs with subsequent reduction in late complications.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
155
161
https://svuijm.journals.ekb.eg/article_153155_b4a6c430c727ea27d94a6555203bc856.pdf
dx.doi.org/10.21608/svuijm.2021.64626.1098
Is Helicobacter pylori infection related to chronic idiopathic urticaria :an updated review
Marwa
Abdelaziz
Dermatology, Venerology and Andrology, Faculty of Medicine, South Valley University. Qena, Egypt
author
Ali
Sayed
Tropical medicine and Gastroenterology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Hassan
Ibrahim
Dermatology, Venerology and Andrology, Faculty of Medicine, South Valley University. Qena, Egypt
author
Eisa
Hegazy
Dermatology, Venerology and Andrology, Faculty of Medicine, South Valley University. Qena, Egypt
author
text
article
2021
eng
Background : there are many causes involved recently to explain the mechanism of chronic idiopathic urticarial or its resistant to treatment one of these is the presence of Helicobacter pylori which related to GIT infections in these patients, they may complaining it like nausea, vomiting or abdominal pain or may be asymptomatic.multiple methods could be used to confirm the diagnosis; invasive and non - invasive maneuvers the most cheap and available one is the stool antigen test from stool analysis which give real Results from the intial days of infection and used to follow up the patients. The aim of this review article is to evaluate the effect of eradication therapy for H.pylori on chronic urticarial patients Conclusion: There is significant association of Helicobacter pylori infection with chronic urticaria. Eradication of H. pylori using triple or most Recent quadrable therapy is a valid therapeutic option for patients with chronic idiopathic urticaria and positive stool antigen test.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
162
165
https://svuijm.journals.ekb.eg/article_120946_d1310bea296cffb0c64a7f8b93d9a2c1.pdf
dx.doi.org/10.21608/svuijm.2020.43134.1004
Managing Diabetic Patients during the Coronavirus Disease (COVID-19) Pandemic
Ghada Mohammed
Ahmed
Histology Department- Faculty of Medicine – Sohag University, Sohag, Egypt
author
text
article
2021
eng
On March 11, 2020, the outbreak caused bySARS-CoV-2 that is identified as the coronavirus disease 2019 (covid-19) was considered as global pandemic. Covid-19pandemic has wide spread worldwide. The risks, morbidity and case fatality of covid-19 are associated with chronic diseases such as cardiac, renal diseases and diabetes mellitus. Recent studies reported that individuals with type1 and those with type2 diabetes are at risk of sever covid-19. The reasons for poor outcome in diabetic patients may be due to multiple factors as longstanding diabetes, old age, obesity and comorbidities such as cardiac disorders. Anti-hyperglycemic drugs can increase the risk. Sever covid-19 can be worsening factor for individuals with diabetes. Covid-19 may lead to dysregulation of blood glucose in individuals with diabetes above that caused by stress hyperglycemia. It may cause acute metabolic complications such as diabetic ketoacidosis. This review discussed the interactions between novel coronavirus infection and diabetes mellitus.The comprehension of this association can help face covid-19 pandemic and future challenges. Conclusion: Diabetes mellitus is related with high risk for occurrence and prognosis of covid-19 infection. There is several studies proved that diabetes increases viral entry into the cell and inflammatory reaction to the infection. This is necessary to regulate the glucose level in diabetic patients with SARS-CoV-2. Patient with mild covid-19 must be under medical advice. Diabetic patients with sever covid-19 must be hospitalized.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
166
171
https://svuijm.journals.ekb.eg/article_127384_d0c272049cca3b8e94a1a48d95b8c0db.pdf
dx.doi.org/10.21608/svuijm.2020.51252.1049
Emerging role of the immunotherapy in treatment of breast cancer
Nagwa Abd El-Sadek
Ahmed
Pathology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Maisa Hashem
Mohammed
Pathology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
author
text
article
2021
eng
Background: Breast cancer is a life-threatening malignant tumor that ranks the most frequent cancerin females worldwide. Emerging studies suggest the important role of the immunotherapy in breast cancer.Triple negative breast cancer (TNBC) is associated with the worst prognosis and is resistantto the conventional therapeutic agents. Recently, the immunotherapy has achieved satisfactory results in the treatment of breast cancer in general and in TNBC in particular. The immune checkpoints are targeted in many clinical trials. The checkpoint inhibitors results in advances in treatment of breast cancer, especially refractory molecular subtypes. This review is aimedto highlight the current knowledge on the immunotherapy and the advances in its implications in treatment of breast cancer with emphasis on newly approved therapeutic approaches in this field. Conclusion: The immunotherapy is considered as an emerging therapeutic strategy for treatment of breast cancer, particularly TNBC.Several clinical trials focusing on the potential role of immunotherapy in breast cancer are still under research.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
172
176
https://svuijm.journals.ekb.eg/article_122698_4451529fb705c3511b08801eb75748c6.pdf
dx.doi.org/10.21608/svuijm.2020.47814.1018
Comparison of Two Levels of Mesh Fixation to the Anterior Vaginal Wall During Sacrocolpopexy
Mohammad
Ahmed
Department of obstetrics and Gynecology, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Background: Vaginal surgery was the traditional way to manage uterovaginal prolapse. However, it has a high rate of recurrence. Aims: this study aimed to compare the outcomes of abdominal hysterectomy and sacrocolpopexy using short and long vaginal mesh arms in women with uterovaginal prolapse. Patients and Methods: We conducted a retrospective cohort study of women with uterovaginal prolapse. The study included 185 patients. The patients were divided into two groups. Each patient underwent abdominal hysterectomy and sacrocolpopexy. Sacrocolpopexy was done using a Y-shaped polypropylene mesh. The posterior arm was fixed to the posterior vaginal wall down to the level of the levator ani. The anterior arm was fixed to the anterior vaginal wall to a variable distance of 2 to 3 cm in the short arms group or down to the trigone in the long arms group. Results: The use of long arms mesh was associated with significantly lower rate of recurrence. Eighty percent of recurrence occurs in the short arm group. In comparison, 20% of recurrence occurs in the long arm group. There was no repeat surgery in the long arms group compared with 4% in the short arms group. Conclusion: In women with uterovaginal prolapse, abdominal hysterectomy and sacrocolpopexy using long vaginal mesh arms appears to result in a lower rate of recurrence compared to abdominal hysterectomy and sacrocolpopexy using short vaginal mesh arms.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
177
184
https://svuijm.journals.ekb.eg/article_117273_1810c3a9c70aafb16529530913e24873.pdf
dx.doi.org/10.21608/svuijm.2020.44182.1011
Potential protective effect of vitamin D on aortic tissue of Streptozotocin-induced diabetic vascular damage in adult male rats
Nahla
Ismail
Human Anatomy and Emberyology, Faculty of Medicine, South valley University , Qena, Egypt
author
Dorreia A.M.
Zaghloul
Human Anatomy and Embryology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Wafaa
Mubarak
Human Anatomy and Embryology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Ayman
Amer
Human Anatomy and Embryology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
author
text
article
2021
eng
Background: Diabetes mellitus is a major risk factor of cardiovascular disease. There is evidence that vitamin D decreases type 1 diabetes mellitus risk during early adulthood and improves insulin secretion and resistance in diabetic patients. low vitamin D level was observed to increase the cardiovascular disease. Objectives: This study aimed to assess the protective effect of vitamin D on diabetic vascular damages in aorta. Materials and Methods: 40 adult male rats were randomly divided into: group I(control), group II (vitamin D), group III (diabetic) and groupVI (diabetic plus Vitamin D)(n = 10 rats /each group). Injection of streptozotocin (60 mg/kg) as a single dose intraperitoneal to induce diabetes. Vitamin D was administered orally every other day in a dose of 12.5 mg/kg. After 12weeksof treatment period, aortic samples were collected for histological examination. Results: Morphological changes of aortic tissue in diabetic untreated group in the form of reduction of tunica media thickness and areas of tunica intima detachment. The elastic lamellae became irregular, fragmented or branched. Shrunken dark or lysed nuclei of smooth muscle fibers were seen in tunica media of diabetic group. The diabetic treated group with vitamin D showed more or less normal structure of the layers of aortic tissuewith comparable thickness to the control group. Conclusion: Vitamin D may reduce the vascular complications and tissue injuries induced by diabetes in aorta. This effect has a positive influence on the function of the cardiovascular system. Keywords: Diabetes, Vitamin D, Aorta.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
185
195
https://svuijm.journals.ekb.eg/article_116070_c96f8ac5d715214c01fda9d0e93e5a50.pdf
dx.doi.org/10.21608/svuijm.2020.43151.1005
Multidrug resistant tuberculosis in Qena governerate and it's socioeconomic burden
Alaa
Rashad
Chest Department,Faculty of Medicine, South Valley University,Qena,Egypt
author
M.Sh
Badawy
chest department,luxor faculty of medicine,luxor university, luxor, egypt
author
Kirolos
Shenouda
Chest Department,Faculty of Medicine, South Valley University,Qena,Egypt
author
text
article
2021
eng
Background: Resistance to tuberculosis (TB) drugs is a formidable obstacle to effective TB care and prevention globally. Patients and Method: This study included 100 patients of both sexes were chosen from outpatient clinic and inpatient word in Qena University hospital. Patients were subjected to: Full history and examination, chest X-Ray, ESR, CBC, sputum microscopic examination, Genexpert for sputum samples, sputum cultures. Results: : Patients with treatment failure were 64 with mean age 48.9±16.1 and 34.4% of patients were male and 65.6% females. The mean ESR in was 1ST hr 101 and after 2nd hr 120. About 43.8% stopped working and 38.5% borrowed money. Chest x-ray showed 50.1% cavitary lesion, 21.8% consolidation, and 28.1% miliary shadow. Patients with treatment response were 36 with mean age 57.3±19.3, about 55.6% of them males and 44.4% females. The mean ESR 1ST hr 54±24, 2ndhr 96.1±32.Chest x-ray showed 22.2% cavitary lesion, 44.4%consolidation and 33.4% miliary shadow. About 38.9% stopped working and 55.6% borrowed money. Conclusion: This study showed increase social and economic burden in TB resistant patients. We noticed that TB resistant patients were reported income loss and work affection.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
196
202
https://svuijm.journals.ekb.eg/article_116287_17528c54494dbf687b150e58c5ae3124.pdf
dx.doi.org/10.21608/svuijm.2020.42683.1006
The role of uterine artery embolization in management of abnormal uterine bleeding
Ahmed
khalaf-Awad M.
Department of Diagnostic and Intervention Radiology, Faculty of Medicine, South Valley University, Qena 83523, Egypt.
author
Ahmed Hashim
Abdellah
Department of Obstetrics & Gynecology, Faculty of Medicine, South Valley University, Qena 83523, Egypt
author
Ahmed Okasha
Mohamed
Department of Diagnostic and Intervention Radiology, Faculty of Medicine, South Valley University, Qena 83523, Egypt.
author
Ghada M.
Abdelrazek
Department of Diagnostic and Intervention Radiology, Faculty of Medicine, South Valley University, Qena 83523, Egypt.
author
text
article
2021
eng
Background:Abnormal uterine bleeding is a common presenting symptom in the family practice setting. The most common causes are uterine fibroids, dysfunctional uterine bleeding and adenomyosis. All conditions were accompanied by chronic blood loss disabling normal lifestyle with variable degrees of morbidity. Objectives: This study is aiming to evaluate the safety, efficacy, and complications of uterine artery embolization(UAE) in the management of abnormal uterine bleeding (AUB)in different age groups. Patients and Methods: This a prospective randomized clinical trial prospective study included 20 patients referred for UAE. Twelve patients had uterine fibroids, 4 patients had adenomyosis and other 4 patients were diagnosed as dysfunctional uterine bleeding. The embolizing materials were used includingPolyvinyl alcohol, Tris- acryl gelatin microspheresand gelatin sponge. All patients had AUB. Results: Most patients showed good therapeutic responses through the follow up period (6-12 months). Complete control of bleeding was achieved in 90% of patients and recurrence occurred only in 10%. There was complete improvement of the pelvic pain and bulk related symptoms. Reduction of uterine and fibroid size occurred with average uterine and dominant fibroid volumes loss of 39%, and 57% respectively. However, the reduction in the Junctional zone thickness was 5.6 %. Conclusion: UAE is considered minimally invasive, safe, and effective method that plays an important role in treatment of variable types of AUB causes, aiming for uterine preservation and avoiding hysterectomy giving the chance for future fertility. It has high success rate with obvious low morbidity and mortality rates.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
203
211
https://svuijm.journals.ekb.eg/article_184906_5dc0c32a9cbfa65052cfb855318bef46.pdf
dx.doi.org/10.21608/svuijm.2021.84539.1192
Endoscopicaly assisted microdebrider adenoidectomy versus conventional curettage adenoidectomy
Aida A.
Abdelmaksoud
ENT Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Alshimaa A.
Gahlan
ENT Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Zaki
Aref
ENT Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Usama K.
Tayee
ENT Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Background: Adenoidectomy by conventional method is an old procedure. Several new techniques discovered in this field as an electronic molecular resonance, suction diathermy, microdebrider, endoscopy, and laser. Objectives: to assess advantages of endoscopic assessed microdebrider adenoidectomy over the conventional method intra and post operative. Patients and methods: 218 patients were scheduled for adenoidectomy were divided into two groups) underwent conventional curettage, group B (106 patients) underwent endoscopic assessed microdebrider. Follow up for 2 weeks ended by endoscopic evaluation. Results: This study included 218 patients (110 males and 108 females) aged 2 years till 14 years, divided randomly into two groups group A 112 patients group B 106 patients. This study reported statistically longer time of operation in group B than group A (13.7 for group B ± 3.5 versus 3.5 ± 1.3). Blood loss was statistically more in group A ((26.7 ± 7.5 for group A versus 17. 9 ± 5.2). Adenoid tissues remnants in group A were statistically higher than group B (27.4 % ± 11.6 for group A versus 1.7% ± .86). Regarding pain it was significantly lower in group B in the six day (4.2 ± 1.2 for group A versus 2.3 ± .5). Conclusion: endoscopic assessed adenoidectomy is significantly better than conventional adenoidectomy regarding blood loss, post operative remnants and post operative pain.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
212
218
https://svuijm.journals.ekb.eg/article_122915_d7c47bc4bf138cbfcebd4f30f8dcbf17.pdf
dx.doi.org/10.21608/svuijm.2020.48686.1033
COX-2 “Cyclooxygenase 2“as a Prognostic marker in Breast Cancer
Fatma Zakaria
Abdel-rahman
Department of Medical Oncology and Hematology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
author
Amen H.
Zaky
Department of Medical Oncology and Hematology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
author
Ashraf
Zedan
Department of Medical Oncology and Hematology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
author
Tarek M.
Elsaba
Department of Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
author
Adel
Gabr
Department of Medical Oncology and Hematology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
author
text
article
2021
eng
Background: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in both developed and developing countries. Globally, the incidence rate of breast cancer has been rising rapidly over the past few decades.Cycloxygenase-2 (COX-2) regulates tumor growth, invasion and metastasis in breast cancer. Objective: The objective of our study is to evaluate COX-2 expression in breast cancer as a poor prognostic factor. Methods: Formalin-fixed and paraffin-embedded tissue blocks were studied for COX-2 expression by immunohistochemistry in 100 patients diagnosed as breast carcinoma. The relationship between COX-2 expression and various clinico-pathological parameters was studied. Results: The results of our study suggest an association of the expression of COX-2 to the poor prognostic factors in breast cancer, such as larger tumor size, positive lymph node status, higher T stage and N stage as studying the association between Cox-2 protein expression and different clinco-pathologic features revealed that larger tumor size (> 5) and lymph node metastasis showed statistical significant association with Cox2 protein expression (p = 0.014 and p < /em> = 0.031, respectively). While rest of clinico-pathologic features such as age, stage, hormonal receptor status, HER2/NEU and histopathological features showed no statistical significant association. Conclusion: Our study established the role of COX-2 in carcinogenesis and its association with adverse prognostic factors.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
219
230
https://svuijm.journals.ekb.eg/article_145930_4308eaf5852b614b358d7de154a91fa2.pdf
dx.doi.org/10.21608/svuijm.2021.60466.1071
Evaluation of minimally invasive versus conventional total hip replacement
Ahmed Khairy Mahmoud
Awad
Department of Orthopaedics, Faculty of Medicine, South Valley University, Qena,83523, Qena Governorate, Egypt
author
Hamdy
Tammam
Department of Orthopaedics, Faculty of Medicine, South Valley University, Qena,83523, Qena Governorate, Egypt
author
Elsayed
Said
Department of Orthopaedics, Faculty of Medicine, South Valley University, Qena,83523, Qena Governorate, Egypt
author
Hesham Hamed
Refae
Department of Orthopaedics, Faculty of Medicine, Aswan University, Aswan City, Aswan Governorate, Egypt
author
text
article
2021
eng
Background: Total hip replacement (THR) is considered a low-risk and efficient procedure, to improve pain and disability not exposing patients to significant risk burden. Minimally invasive (MIS) approaches of THR are not only desired to add more benefits but also shouldn`t compromise the already accomplished long-term results. Objectives: The purpose of our study was to evaluate the surgical outcome of minimally invasive versus conventional approach total hip arthroplasty. Patients and methods: This study was performed through a prospective; study comparing two patient groups containing 30 patients who had1ry hip replacement (THA) during the period from March 2018 to May 2020 at Qena University Hospital, fifteen of them undergone 1ry THA utilizing conventional approach and the other fifteen patients undergone 1ry THA utilizing mini-invasive approaches. Results: In Conventional THA group (group-A) nine males and six females were included with a mean age (± SD) of 57.2 ± 4.3 years; ranging (50-65 years). Preoperative HHS in-group-A patients ranged 20.3 – 37.1 (mean 26.8 ± 4.7). In Minimally invasive THA group (group-B) eight males and seven females were included with a mean age (± SD) of 57.7 ± 5.1 years; ranging (49-66 years).Preoperative HHS in group-B patients ranged 20.5 – 48.8 (mean 31.1 ± 8.0).The post-operative HHS were 89.56 ±6.11 and 91.94 ±1.91 in the group-A and group-B respectively, no statistically significant variation regarding the mean values was discovered between the two groups. The mean time to resume work in the group-A was 6.87 ±2.23 weeks compared to 5.67 ±1.39 weeks in the group-B with a significant statistical increase regarding group-A. Conclusion: MIS approaches are advantageous in the terms of hospitalization and time to return to work.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
231
239
https://svuijm.journals.ekb.eg/article_186071_06c556c04db59934f58a0a47b3f8ef6a.pdf
dx.doi.org/10.21608/svuijm.2021.83252.1195
Totally versus planned conversion laparoscopic colectomy for colorectal cancers: the beginning of the learning curve
Mahmoud A.
Abozeid
Department of General Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Ahmed A.
Abou-Zeid
Department of General Surgery, Faculty of Medicine, Ain Shams University, Ain Shams, Egypt
author
Hamdy Mohammed
Hussein
Department of General Surgery, Faculty of Medicine, Luxor University, Luxor, Egypt.
author
Mohamed Ahmed
Omar
Department of General Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
text
article
2021
eng
Background: Colorectal cancers (CRC) are one of the major causes of cancer-related deaths worldwide. Laparoscopic colectomies have many advantages in short-term outcomes in comparison with open colectomies and recently have a long-term oncologic validation. Objectives: This work aimed to compare the short- and medium-term outcomes of TLC and LPCC for CRC at the beginning of the learning curve of laparoscopic colectomy. Materials and Methods: A randomized prospective study has been conducted from November 2018 to November 2020 on 30 patients with CRC were randomized to the total laparoscopic colectomy (TLC) group (15 patients) or laparoscopic-planned conversion colectomy LPCC group (15 patients). The primary outcomes were operative time, intra-operative blood loss, postoperative pain, hospital stay, and the secondary outcomes were early postoperative complications (anastomotic leak, pelvic nerve injuries), tumour recurrence, port-site metastasis, and hernia.Results: There were statistically significant differences in the operative time (244± 40.9min vs. 322 ± 57 min; P <0.001) and in the intra-operative blood loss (240± 118.3 cc vs. 326.7 ± 99.8 cc; P < 0.039). There were no statistically significant differences in the post-operative pain, hospital stay, early postoperative complications, tumour recurrence, port-site metastasis, and hernia. Conclusion: Laparoscopic planned conversion colectomy is a safe and feasible procedure in the management of selected patients with colorectal carcinoma especially at the beginning of the learning curve of laparoscopic colectomy with differences in the operative time and the intra-operative blood loss that need further studies to evaluate these differences and the possibility of being less significant.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
240
245
https://svuijm.journals.ekb.eg/article_188307_dd6548194723dfd52e0c57073257e759.pdf
dx.doi.org/10.21608/svuijm.2021.83691.1189
Evaluation of high cut Dega osteotomy for management of developmental hip dysplasia in children
Hesham Hamed
Refae
Department of Orthopaedic Surgery, Faculty of Medicine, Aswan University, Aswan, Egypt.
author
Elsayed
Said
Department of Orthopaedic Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
Mohamed Tageldeen
Elemary
Department of Orthopaedic Surgery, Faculty of Medicine, Cairo University, Cairo, Egypt
author
Emad Hamdy Morsy
Ahmed
Department of Orthopaedic Surgery, Faculty of Medicine, South Valley University, Qena, Egypt.
author
text
article
2021
eng
Background: Developmental dysplasia of the hip (DDH) is a spectrum of pathologic changes affect the developing hip. Dega acetabuloplasty is considered one of the favorable reshaping procedures and it is most valuable in severe dysplasia without need for internal fixation. High cut Dega osteotomy is a modification for the typical Dega procedure by making the osteotomy at a higher level close to salter osteotomy. So, it facilitates the basic Dega procedure and produces a Salter-like effect.
Objectives: to evaluate theclinical and radiological outcomes of the management of DDH by high cut Dega osteotomy.
Patients and Methods: This prospective study included 20 patients with 25 involved hips who presented with DDH between walking age and under 3 years of age, High cut Dega osteotomy were conducted in 13 patients in Abo-Elreesh-Hospital and 7 patients in Qena University Hospital between March 2017 and March 2021.
Clinical status was assessed using modified McKay criteria; radiological evaluations were assessed using the modified Severinclassification, the mean acetabular index (AI),and centeredge (CE) angles.
Results: The final clinical resultswere satisfactory in 24 hips (96%) and unsatisfactory in one (4%), there was a statistically significant improvement in acetabular index and center edge at the final follow up.
Conclusions: Our modified technique gives similar results to the Dega procedure but avoid iatrogenic insults to the acetabulum and rare early closure of the triradiated cartilage, which might lead to acetabular dysplasia.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
246
256
https://svuijm.journals.ekb.eg/article_188809_23b667f4318d4fd027d97e1f2a9caa08.pdf
dx.doi.org/10.21608/svuijm.2021.85447.1196
Clinicopathological Characteristics and Androgen Receptor Expression of Triple Negative Breast Cancer: A Retrospective Study in Upper Egypt
Eman Mostafa
Masoud
Department of Pathology, Faculty of Medicine , Assiut University, Assiut, Egypt
author
Nermeen Abdel-Moneim H.
Kamel
Department of Pathology, Faculty of Medicine , Assiut University, Assiut, Egypt
author
Ahmed Mohamed Ali
Ali
Department of General Surgery, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Dalia Ahmed Hamed
Elsers
Department of Pathology, Faculty of Medicine , Assiut University, Assiut, Egypt
author
text
article
2021
eng
Background: Breast cancer is a big challenging problem for public health. Triple negative breast cancer (TNBC) is a subtype of breast cancer which is more aggressive; with no specific treatment guidelines are available. It was noted that androgen receptor (AR) is expressed in TNBC, suggesting that anti-androgens are a promising strategy for treatment. Recently, it was found racial differences in the biologic behavior of TNBC.
Objectives: This study aims to assess the clinicopathological features of TNBC in Upper Egypt, and to evaluate the immunohistochemical (IHC) expression of AR in TNBC, in comparison to hormone receptor positive (HR+) invasive duct carcinomas (IDC) as a control group.
Patients and Methods: IHC expression of AR was examined in 45 TNBC specimens and 15 HR+ IDC (ER+ and PR+/-).
Results: Most of the TNBC cases were ≤50 years and their tumors had high histological grade, presence of lymphovascular emboli, lymph node metastasis and tumor necrosis while few cases revealed duct carcinoma in situ (DCIS) and most patients were stage I & II.TNBC group had significantly younger age, DCIS, higher nodal metastasis and necrosis compared to control group. AR expression was significantly higher in the control group.
Conclusion: TNBC occurs at young age and is associated with poor clinicopathological criteria, suggesting the presence of underlying BRCA mutations in our population. AR was expressed in a subset of TNBC, this makes AR an interesting drug target for those patients. Further molecular studies are recommended to uncover pathways of TNBC pathogenesis and improve its therapeutic options.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
257
268
https://svuijm.journals.ekb.eg/article_192858_5be442deff7253c76d24d15a80b2edd0.pdf
dx.doi.org/10.21608/svuijm.2021.89232.1203
The role of magnetic resonance imaging and magnetic resonance diffusion weighted image in preoperative staging of rectal cancer in comparison to postoperative histopathology
Hamdey M.
Hussien
General Surgery Department, Faculty of Medicine, Luxor University, Luxor, Egypt
author
Ahmed
Okasha
Diagnostic Radiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Hind
Nabil
Diagnostic Radiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
Abdelhay A.
Abdelhay
Diagnostic Radiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
author
Mahmoud Abdelaziz Mohalil
Orabi
Diagnostic Radiology Department, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Background: With outstanding soft tissue contrast, functional imaging capabilities, and multiplanar capacity, high-resolution phased-array magnetic resonance imaging MRI is considered as a basic imaging modality for preoperative local staging of rectal cancer. And so MRI fills a void in clinical practice by allowing for precise local staging of rectal cancer prior to treatment decisions. The diffusion-weighted image used as enhancing utility for MRI in patients with rectal cancer. Objectives: The aim of work was to assess the role of MRI imaging including the (diffusion weighted imaging DWI and Apparent diffusion coefficient ADC map) in preoperative rectal cancer staging, in comparison to post-operative histopathology. Patients and methods: A total of 50 patients were included in the study, presented to South Valley University hospital and underwent MRI examination in MRI unit at South Valley University hospital. Results: Regarding the circumferential resection margin (CRM) infiltration, MRI diagnosed CRM involvement in 15 cases while rest 35 cases showing free CRM. From these positive cases only 13 were truly positive with histopathology, other two cases proved to be positive with histopathology not diagnosed by MRI. MRI showed MRF infiltration in only 18 cases. Histopathological assessment showed that MRF infiltration in only 15 cases and the rest 35 cases showing free MRF (agreement 83.3%). Conclusion: The results of this study demonstrate that preoperative MRI has a great value in achieving the best treatment strategy through accurate staging of rectal cancer, prediction of negative CRMs and involvement of the perirectal and pelvic LNs.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
269
276
https://svuijm.journals.ekb.eg/article_194044_5116d67485cdfc4cc1bf28811de22d77.pdf
dx.doi.org/10.21608/svuijm.2021.90832.1208
Diagnostic Role of Ultrasonography Compared to Magnetic Resonance Imaging in Ankle Pain
Abdelrahman Amer Bakir
Ali
Department of Diagnostic Radiology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ahmed
Okasha
Department of Diagnostic Radiology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ghada M.
Abdelrazeq
Department of Diagnostic Radiology, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Background: Ankle pain is common in clinical practice. Various lesions including trauma, impingement syndromes, inflammatory arthritis, soft tissue, and bony lesions affect the ankle joint. Imaging is crucial in the determination of the pain cause and management.
Objectives: This study aimed to evaluate the role of high-resolution musculoskeletal ultrasonography (MSK US) compared to the role of magnetic resonance imaging (MRI) in ankle pain.
Patients and Methods: This studyconducted on 29 patients who presented with ankle pain during the period from September 2018 until September 2019 at Qena University Hospitals, South Valley University, Egypt and evaluated by plain radiographs, US and MRI. Comparative analysis was done between US and MRI.
Results: The US was able to detect various lesions affecting the ankle ( tendinous and ligamentous injury, plantar fasciitis, joint effusion, bursitis, ganglion cysts, tarsal tunnel syndrome) with sensitivity and specificity of 100% regarding tendons pathology and sensitivity 80 %, specificity 100 % regarding ligamentous injuries with overall accuracy 95 % compared to MRI. US was negative in all MRI positive bony lesions.
Conclusion: The US is a useful imaging modality in identifying a large spectrum of causes of ankle pain and should be considered a first step diagnostic tool when an osseous lesion is not suspected.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
277
285
https://svuijm.journals.ekb.eg/article_194334_208e96c59516e791fec7de68d07beb0f.pdf
dx.doi.org/10.21608/svuijm.2021.90933.1210
Microwave ablation versus Radiofrequency ablation in the management of Hepatocellular carcinoma
Hasan S.
Mahmoud
Tropical Medicine and Gastroenterology Department, Faculty of Medicine, South Valley University,
Qena, Egypt
author
Shimaa
Arafat
Tropical Medicine and Gastroenterology Department, Faculty of Medicine, South Valley University,
Qena, Egypt
author
Saad
Zaky
Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut,
Egypt
author
Shamardan Ezzeldin S.
Bazeed
Tropical Medicine and Gastroenterology Department, Faculty of Medicine, South Valley University,
Qena, Egypt
author
text
article
2021
eng
Background: Different loco-regional therapies have been progressed for irresectable liver tumors to achieve local tumor control. Examples of loco-regional therapies are different thermal ablation therapies such as microwave ablation, and radiofrequency ablation.
Objectives: We aimed to evaluate treatment safety, efficacy, and complications related to radio-frequency ablation (RFA) in comparison with percutaneous microwave (MW) ablation for the management of HCC.
Patients and Methods: 100 patients presented with liver cirrhosis and HCC proved by imaging ultrasonography and triphasic CT. Patients were assigned into two main comparison groups:
Group 1: patients with single or multiple hepatic focal lesions (size up to 4cm) who received RFA. Group 2: patients with single or multiple hepatic focal lesions (size up to 4cm) who received MWA. Complete blood count, liver function tests, and AFP were measured for all subjects.
Results: In All 100 patients; the assessment number of the hepatic focal lesion was done by abdominal ultrasonography and triphasic CT 93% of patients had a single focal lesion with a median size of 2.3cm. Group (1): (who were candidates for RFA) showed statistically significant higher values as regard (ALT) (p-value =0.091) compared to group (2): (who were candidates for MWA).
There were no statistical differences between both groups as regard Total Bilirubin and serum AFP. The microwave ablation group was statistically significant as regard ablation success, shorter time, and shorter ablation than the radiofrequency ablation group (p-value =0.000).
Conclusions: RFA and MWA are good ablative techniques. MWA showed more superiority than RFA in the overall outcome.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
286
292
https://svuijm.journals.ekb.eg/article_194572_aa4c63a0993c5a010c761d0ca5c85c3a.pdf
dx.doi.org/10.21608/svuijm.2021.89036.1202
Role of Ultrasonography and power Doppler of Wrist and Hand Joints in Diagnosis of Early Symptomatic Cases of Rheumatoid Arthritis.
Ahmed
Okasha
Department of Diagnostic Radiology, Faculty of Medicine, South Valley University , Qena , Egypt.
author
Hend Nabil
Mahmoud
Department of Diagnostic Radiology, Faculty of Medicine, South Valley University , Qena , Egypt.
author
Waleed Nashaat
Abd Ellah
Department of Diagnostic Radiology, Faculty of Medicine, South Valley University , Qena , Egypt.
author
text
article
2021
eng
Background: Rheumatoid arthritis disease is a chronic inflammatory disease, characterized by development of synovitis, which damages cartilage, bone, ligaments and tendons. High resolution ultrasound has become an established imaging technique for the diagnosis and follow-up of patients with rheumatoid arthritis
Objective: The study was conducted on early symptomatic cases of Rheumatoid Arthritis that referred to Radiology out clinic in Qena General Hospital, to evaluate the role of gray scale ultrasound and power Doppler in the diagnosis.
Patients and methods: The total numberwas30 patients, 25 females and 5 males suffering from rheumatoid arthritis. Patients examined by GE LOGIQ P5 ultrasound machine using a near focused linear array transducer with color Doppler and by Plain X ray radiographs.
Results: Results showed the following: Synovial thickening was detected in 22 patients (73%), active synovitis was detected by Doppler US in 13 patients (43%), Effusion was detected in 15 patients (50 %), and Bone erosions were detected in 5 patients (17%) and X-ray finding was detected in 4 patients (13 %).
Conclusion: HRUS with PD is an efficient technique to assessment of (RA) patient and evaluation of vascularity, differentiate between inactive and active synovial hypertrophy and has the potential role in diagnosis, assessment and follow up of the patients with RA therapy.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
293
302
https://svuijm.journals.ekb.eg/article_195953_a6b4ffd9d16f4d94c05d673c84a286ac.pdf
dx.doi.org/10.21608/svuijm.2021.92362.1213
Excessive Daytime Sleepiness among Chronic Kidney Disease Patients
Suzan S.
Sayed
Department of Chest Diseases, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Samah
Kotb
Department of Chest Diseases, Faculty of Medicine, Aswan University, Aswan, Egypt
author
Amany
Omar
Department of Chest Diseases, Faculty of Medicine, Assiut University, Assiut, Egypt
author
Shazly
Ahmed
Department of Chest Diseases, Faculty of Medicine, Aswan University, Aswan, Egypt
author
text
article
2021
eng
Background:Excessive daytime sleepiness is defined as the incapacity to keep alert or awake during the major waking activities of the day, causing unintentional pauses of drowsiness or sleep. Chronic kidney diseasepatients commonly suffer from excessive daytime sleepiness which in turn affectstheir quality of life.
Objectives: This prospective cross-sectional study was conductedto evaluate the prevalence of excessive daytime sleepiness among chronic kidney disease patients.
Patients and methods: The study was carried out on one hundred patients with known chronic kidney disease who attended Aswan University hospital during the period between May 2017 and March 2020; 42.0% males and 58.0% females with a mean age of 53.9 ± 16.97 years. We evaluated day time sleepiness among those patients using Epworth Sleepiness Scale (ESS); the standardized score for the assessment of daytime sleepiness.
Results: We found that 56% of the patients had excessive daytime sleepiness (ESS > 10) with themedian ESS of the participants was 10.0.There was no statistically significant correlation between the ESS and each of serum urea, serum creatinine, and eGFR.
Conclusion:Excessive daytime sleepiness is common among CKD patients with a prevalence of 56% that may affect their quality of life.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
303
312
https://svuijm.journals.ekb.eg/article_196867_d34dc0041f2c6483852920c6b4aadb34.pdf
dx.doi.org/10.21608/svuijm.2021.93667.1216
Role of MR arthrography In Assessment of Glenohumeral Instability
Hamdan Abdelhameed
Aly
Department of Radio-diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Mohammad Hassan
Alkousy
Department of Radio-diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Khaled Fawzy
Zaky
Department of Radio-diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt
author
Mohammad Tharwat Mahmoud
Solyman
Department of Radio-diagnosis, Faculty of Medicine, Sohag University, Sohag, Egypt
author
text
article
2021
eng
Background: The glenohumeral joint has a unique structure which allows for the widest range of motion among all joints in the human body; however this unfortunately makes the joint inherently unstable. Various imaging techniques are available for assessment of shoulder joint abnormalities. Magnetic resonance arthrography is considered the best modality for the assessment of disorders related to shoulder instability. The injection of para magnetic contrast solution into the joint cavity induced distension of the capsule allowing separation of the intra articular structures and beret visualization of shoulder disorders. However, arthrography is a time-consuming, minimally invasive procedure, which, although generally safe, it might carries some risks like hemorrhage and infection. Objectives: The aim of this work was to evaluate the diagnostic performance of MR arthrography (MRA) in the detection of shoulder disorders in patients having shoulder instability. Patients and methods: Between February 2017 and March 2021, 50 patients with a clinical diagnosis of shoulder instability were examined by MR arthrography. MR arthrographic finings including the different labral tears, rotator-cuff tears (RCTs) and Hill–Sachs lesions were recognized and compared to surgical arthroscope ‘ the gold standard’. Sensitivity, specificity, accuracy, PPV and NPV were calculated for MR arthrography. Results: MRA showed sensitivity and specificity of about 90% for the detection of classic Bankart lesions, sensitivity of 91.8 and specificity of 100%, for detecting bony Bankart lesions, sensitivity and specificity of 91.6 %, and 100% for the detection of SLAP lesions. The sensitivity and specificity for the detection of Hill-Sachs were 92.31%, 100% respectively; the sensitivity and specificity in the detection of RCTs were 95.24% and 100%. Conclusion: MR arthrography has a high diagnostic performance in the detection of different labral tears. RCTs (in particular partial thickness RCTs) and Hill–Sachs lesions.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
313
326
https://svuijm.journals.ekb.eg/article_197400_e2ca5e6e35385e9ce244dbd2a91b598b.pdf
dx.doi.org/10.21608/svuijm.2021.96089.1221
Sleep quality and psychological status of health professionals in Egypt during COVID-19 era
Eptehal M.
Dongol
Chest Disease Department, Qena Faculty of Medicine, South Valley University,Qena, Egypt
author
Alia A.
Saleh
Psychiatry Department, Faculty of Medicine, Cairo University, Cairo, Egypt
author
Aliae AR Mohamed
Hussein
Chest Department Assiut University Hospital, Assiut, Egypt
author
Mohamed Moslem Hefny
Mahmoud
Psychiatry Department , Qena Faculty of Medicine, South Valley University, Qena, Egypt
author
Islam
Galal
Chest Disease Department, Faculty of Medicine, Aswan University, Aswan, Egypt
author
text
article
2021
eng
Background: Good quality sleep is crucial for human well-being. COVID-19 pandemic affected tremendously the quality of life in human specially the health professionals dealing with the patients with COVID-19 in difficult and unusual circumstances.
Objectives: This study aimed to assess the sleep quality among the Egyptian health professionals during the peak of the COVID-19 time and the degree of the psychological distress they have experienced using validated tools and to investigate the link between both.
Patients and methods : this is a cross sectional study. an online survey was distributed through the social media and online platforms to be filled by Egyptian health professional . The survey included the socio-demographic information, work details, Pittsburgh Sleep Quality (PSQI) and the General Health Questionnaire (GHQ-12) amid of the COVID-19 pandemic.
Results : 146 health professionals responded to the online questionnaire which included some epidemiological data, the Pittsburg Sleep Quality Index (PSQI) and General Health Questionnaire-12 (GHQ-12). 60% were females and mean age was 37.47 years. The mean PSQI and the GHQ-12 were 7.8 and 14.55 respectively. More than half of the respondents had some degree of psychological distress and about 67% of them had a poor sleep quality. Moreover, there was a positive association between the GHQ and the PSQI.
Conclusion: Sleep quality among the health professionals was affected and linked to the degree of the psychological distress they experience. This warrants the importance of the psychological support that the health professionals needs especially in the current global situation.
Trial registration: ClinicalTrial.gov, NCT04395300. Registered 19 May 2020. Retrospectively registered,https://clinicaltrials.gov/ct2/show/record/NCT04395300
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
327
340
https://svuijm.journals.ekb.eg/article_197473_5399cf4826cd81640e81824c2c08d5ef.pdf
dx.doi.org/10.21608/svuijm.2021.92429.1215
Comparison of hemodiafiltration and hemodialysis in patients with uraemic pruritus
Mohammed Abdelrazek
Elsenbsy
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt; Internal Medicine Department ,Arabian Gulf University(AGU),Bahrain
author
Abdelrahman Abdelhamed
Elsayed
Department of Clinical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt
author
Ahmed Mohamed Mohamed
Younis
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt
author
AbdelKader Ahmed
Hashim
Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt
author
text
article
2021
eng
Background: Chronic kidney disease (CKD)-associated pruritus is a common complicationin patients with end-stage renal disease. Objectives: To compare the capabilities of hemodialysis (HD) and hemodiafiltration(HDF) in clearing toxins and their effects on pruritus inuremic patients. Patients and methods: The study included 40 adult subjects (18 years or older) who had maintenance dialysis for at least three months. Patients were divided into two groups: Group I: 20 patients underwent maintenance HDF (Intervention group), Group II: 20 patients underwent maintenance HD (Control group). Serum calcium levels, serum phosphorus levels, serum parathormone levels (PTH) and serum B2 microglobulin were assessed. The severity of pruritus measured by the visual analogue scale (VAS). Results: The prevalence of Uremic Pruritus in our study was 52.5% in all studied patients.We found a statistically significant difference (p-value < 0.05) between studied groups as regard Uremic Pruritis.The prevalence of UP was higher in HD group (70 %) in compare with HDF group (35 %). We found a Statistically significant difference (p-value < 0.05) between HDF group & HD group regard B2 mico-globulin &PTH. Levels of PTH and B2 microglobulin were significantly higher in HD group(175.2 ± 36.1pg/ml and 11.3 ± 2.1μg/ml, respectively) as compared with HDF group (207.9 ± 36.4pg/ml and 14.1 ± 4.04μg/ml, respectively). Conclusion: The prevalence and severity of Uremic Pruritus were significantlylower among HDF patients than HD patients. HDF can clear b2-MG and PTH and provide relief from pruritus efficiently more than HD.
SVU-International Journal of Medical Sciences
South Valley University, Faculty of Medicine
2735-427X
4
v.
2
no.
2021
341
347
https://svuijm.journals.ekb.eg/article_198323_34a61d11e1030b4b18e1d3e076070143.pdf
dx.doi.org/10.21608/svuijm.2021.72131.1170